Induction by cocaine of the serotonergic 5-HT3 receptor in rat cerebellum

被引：6
作者：
Arpin-Bott, Marie-Pierre
Dietrich, Jean-Bernard
Dirrig-Grosch, Sylvie
Aunis, Dominique
Zwiller, Jean
机构：
[1] INSERM, Ctr Neurochim, U575, F-67084 Strasbourg, France
[2] Ctr Neurochim, IFR037, F-67084 Strasbourg, France
来源：
CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY: COCAINE, GHB, AND SUBSTITUTED AMPHETAMINES | 2006年 / 1074卷
关键词：
cocaine; serotonin; 5-HT3; receptor; Bergmann glial cells; rat cerebellum;
D O I：
10.1196/annals.1369.038
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The expression of the 5-HT3 receptor, a member of the serotonin receptor family, was examined in rat cerebellum of saline- or cocaine-treated rats. Both immunohistochemistry and Western blot analysis were used. We found that the expression of this serotonin receptor subtype was increased in the cerebellum of rats injected either acutely or repeatedly (1 injection/day for 10 days) with cocaine. The stimulation was more pronounced after a single injection than after a series of 10 injections. Surprisingly, the expression of the 5-HT3 receptor was mainly localized in Bergmann glial cells, as assessed from the co-localization of the receptor with the glial cell marker glial fibrillary acidic protein (GFAP). Our data emphasize the importance of the 5-HT3 receptor induction in the cerebellum as part of the neuroadaptations taking place in rat brain in response to the psychostimulant cocaine.
引用
收藏
页码：382 / 389
页数：8
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