Synthesis of the tetrasaccharide repeating unit of the O-glycan from the polar flagellum flagellin of Azospirillum brasilense Sp7

被引：7

作者：

Pal, Kumar Bhaskar ^{[1
]}

Mukhopadhyay, Balaram ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res, Kolkata 741246, Mohanpur, India

来源：

CARBOHYDRATE RESEARCH | 2014年 / 400卷

关键词：

Flagellin O-glycan; Total synthesis; H2SO4-silica; PSEUDOMONAS-AERUGINOSA; CONCISE SYNTHESIS; GLYCOSYLATION; MOTILITY; LIPOPOLYSACCHARIDE; POLYSACCHARIDE; THIOGLYCOSIDES; IDENTIFICATION;

D O I：

10.1016/j.carres.2014.06.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemical synthesis of the tetrasaccharide repeating unit of the O-glycan from the polar flagellum flagellin of Azospirillum brasilense Sp7 in the form of its p-methoxyphenyl glycoside is reported. The required glycosidic linkages have been accomplished by activation of thioglycosides with N-iodosuccinimide in the presence of H2SO4-silica. H2SO4-silica was found to be an effective alternative to the classical acid promoters like TfOH or TMSOTf and it can lead to the formation of both 1,2-cis and 1,2-trans glycosidic linkages depending on the protecting group manipulation and control of the reaction condition. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：9 / 13

页数：5

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