Progress in the Discovery and Development of Heat Shock Protein 90 (Hsp90) Inhibitors

被引：114

作者：

Bhat, Rohit ^{[1
]}

Tummalapalli, Sreedhar R. ^{[1
]}

Rotella, David P. ^{[1
]}

机构：

[1] Montclair State Univ, Sokol Inst Pharmaceut Life Sci, Dept Chem & Biochem, Montclair, NJ 07043 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2014年 / 57卷 / 21期

关键词：

MOLECULAR CHAPERONE; PHASE-II; SELECTIVE INHIBITORS; IN-VITRO; NOVOBIOCIN; TANESPIMYCIN; EXPRESSION; TOXICITY; SCAFFOLD; BINDING;

D O I：

10.1021/jm500823a

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The discovery and clinical development of heat shock protein 90 (Hsp90) inhibitors continue to progress. A number of Hsp90 inhibitors are in clinical trials, and preclinical discoveries of new chemotypes that bind to distinct regions in the protein as well as isoform selective compounds are active areas of research. This review will highlight progress in the field since 2010.

引用

页码：8718 / 8728

页数：11

共 69 条

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