Vilsmeier-Haack Bromination of Aromatic Compounds with KBr and N-Bromosuccinimide Under Solvent-Free Conditions

被引：14

作者：

Chakradhar, A. ^{[1
]}

Roopa, R. ^{[1
]}

Rajanna, K. C. ^{[1
]}

Saiprakash, P. K. ^{[2
]}

机构：

[1] Osmania Univ, Postgrad Coll, Mirzapur 502249, Sgd, India

[2] Osmania Univ, Dept Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

SYNTHETIC COMMUNICATIONS | 2009年 / 39卷 / 10期

关键词：

Bromination; KBr; N-bromosuccinimide; solvent-free conditions; Vilsmeier-Haack reagent; REGIOSELECTIVE OXIDATIVE BROMINATION; POTASSIUM-BROMIDE; CARBOXYLIC-ACIDS; AMMONIUM-NITRATE; MICELLAR MEDIA; EFFICIENT; FORMYLATION; CYCLIZATION; QUINOLINES; MILD;

D O I：

10.1080/00397910802594268

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bromination of aromatic hydrocarbons is triggered by Vilsmeier-Haack reagent [N,N-dimethyl formamide (DMF-POCl3 system)] in the presence of KBr or N-bromosuccinimide (NBS) under solvent-free conditions by grinding the reactants in a mortar with a pestle. The reactions afforded corresponding bromo derivatives in very good yield with high regioselectivity. The results are comparable with those obtained under reflux conditions.

引用

页码：1817 / 1824

页数：8

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