Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro

被引：323
|
作者：
Wang, Gui-Feng [1 ]
Shi, Li-Ping [1 ]
Ren, Yu-Dan [1 ]
Liu, Qun-Fang [2 ]
Liu, Hou-Fu [3 ]
Zhang, Ru-Jun [2 ]
Li, Zhuang [5 ]
Zhu, Feng-Hua [1 ]
He, Pei-Lan [1 ]
Tang, Wei [1 ]
Tao, Pei-Zhen [5 ]
Li, Chuan [3 ]
Zhao, Wei-Min [2 ]
Zuo, Jian-Ping [1 ,4 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunopharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Mat Med, Lab Nat Prod Chem, State Key Lab Drug Res, Shanghai 201203, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Mat Med, Lab Ctr Drug Metab & Pharmacokinet Res, State Key Lab Drug Res, Shanghai 201203, Peoples R China
[4] Shanghai Univ Tradit Chinese Med, Lab Immunol & Virol, Shanghai, Peoples R China
[5] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100037, Peoples R China
来源：
ANTIVIRAL RESEARCH | 2009年 / 83卷 / 02期
关键词：
Chlorogenic acid; Quinic acid; Caffeic acid; Coffee crude extracts; HBV; ANTIVIRAL ACTIVITY; COFFEE CONSUMPTION; RISK; EXTRACTS; CELLS; DERIVATIVES; INHIBITION; ORIGIN; CANCER; AGENTS;
D O I：
10.1016/j.antiviral.2009.05.002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Chlorogenic acid and its related compounds are abundant plant polyphenols that have a diverse antiviral activity. In this study, HepG2.2.15 cells and duck hepatitis B virus infection model were used as in vitro and in vivo models to evaluate their anti-HBV activity. In the cell model, all the three compounds inhibited HBV-DNA replication as well as HBsAg production. Chlorogenic acid and caffeic acid also reduced serum DHBV level in DHBV-infected duckling model. Moreover, the anti-HBV activity of crude extracts of coffee beans, which have a high content of chlorogenic acid, was studied. Both the extracts of regular coffee and that of decaffeinated coffee showed inhibitory effect on HBV replication. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：186 / 190
页数：5
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