Efficacy of autologous platelet-rich plasma in preventing adhesion reformation following hysteroscopic adhesiolysis: a randomized controlled trial

被引:23
作者
Shen, Minghong [1 ,2 ]
Duan, Hua [1 ]
Lv, Ruju [3 ]
Lv, Chengxiao [1 ]
机构
[1] Capital Med Univ, Beijing Obstet & Gynecol Hosp, Beijing Maternal & Child Hlth Care Hosp Beijing, Dept Gynecol Minimal Invas Ctr, Beijing, Peoples R China
[2] Fujian Med Univ, Fujian Prov Hosp, Dept Gynecol, Prov Clin Med Coll, Fuzhou, Fujian, Peoples R China
[3] Shandong WEGO Grp Med Polymer Co Ltd, Weihai, Shandong, Peoples R China
关键词
Adhesion recurrence; Balloon; Hysteroscopy; Intrauterine adhesions; Platelet-rich plasma; INTRAUTERINE-CONTRACEPTIVE-DEVICE; ASHERMAN-SYNDROME; BALLOON;
D O I
10.1016/j.rbmo.2022.07.003
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Research question: What is the efficacy of platelet-rich plasma (PRP) in reducing adhesion reformation in women with moderate to severe intrauterine adhesions (IUA)? Design: In this randomized controlled trial, women with moderate-to-severe IUA were recruited between November 2019 and June 2021 from a university hospital and randomized into the PRP or control group. The PRP group was treated using an intrauterine-suitable balloon combined with PRP infusion following hysteroscopic adhesiolysis, whereas the control group received only the former intervention. The reductions in adhesion scores from before to after surgery and the adhesion reformation rate were analysed. Results: A total of 123 participants successfully completed the study (PRP group, 63; control group, 60). Age, pregnancy history, menstrual score and American Fertility Society score before surgery were not significantly different between the two groups. At the second-look hysteroscopy, the PRP group had a significantly greater reduction in adhesion score than the control group (7 versus 6, respectively; P = 0.027). The postoperative adhesion reformation rates in the PRP group and the control group were 20.6% and 30.0%, respectively (risk ratio 0.69, 95% confidence interval 0.27-1.38, P = 0.232; number needed to treat 10.6). Conclusions: Intrauterine PRP infusion seems to be beneficial in reducing postoperative adhesion reformation following hysteroscopic adhesiolysis.
引用
收藏
页码:1189 / 1196
页数:8
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