Programmed Negative Allostery with Guest-Selected Rotamers Control Anion-Anion Complexes of Stackable Macrocycles

被引：20

作者：

Sheetz, Edward G. ^{[1
]}

Qiao, Bo ^{[1
]}

Pink, Maren ^{[1
]}

Flood, Amar H. ^{[1
]}

机构：

[1] Indiana Univ, Dept Chem, 800 E Kirkwood Ave, Bloomington, IN 47405 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2018年 / 140卷 / 25期

关键词：

BINDING; MODEL; STABILIZATION; RECOGNITION; ASSEMBLIES; EFFICIENT; FIDELITY; ENTROPY; SINGLE;

D O I：

10.1021/jacs.8b02993

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new rotamer-based strategy for negative allostery has been used to control host-host interactions and product yield upon anion complexation. Coassembly of anion dimers as guests inside two cyanostar macrocycles drives selection of one rotamer in which all ten steric groups get directed outward to destabilize triply stacked macrocycles. A large entropy penalty (Delta S) is quantified upon anion binding when the multiple dynamic rotamers collapse down to one.

引用

页码：7773 / 7777

页数：5

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