Cerebrospinal fluid amounts of HLA-G in dimeric form are strongly associated to patients with MRI inactive multiple sclerosis

被引：11

作者：

Fainardi, Enrico ^{[1
]}

Bortolotti, Daria ^{[4
]}

Bolzani, Silvia ^{[4
]}

Castellazzi, Massimiliano ^{[3
]}

Tamborino, Carmine ^{[3
]}

Roversi, Gloria ^{[3
]}

Baldi, Eleonora ^{[2
]}

Caniatti, Maria Luisa ^{[2
]}

Casetta, Ilaria ^{[3
]}

Gentili, Valentina ^{[4
]}

Granieri, Enrico ^{[3
]}

Rizzo, Roberta ^{[4
]}

机构：

[1] Azienda Osped Univ Arcispedale S Anna, Dept Neurosci & Rehabil, Neuroradil Unit, Via Aldo Moro 8, I-44124 Ferrara, Italy

[2] Azienda Osped Univ Arcispedale S Anna, Dept Neurosci & Rehabil, Neurol Unit, Via Aldo Moro 8, I-44124 Ferrara, Italy

[3] Univ Ferrara, Dept Biomed & Specialist Surg Sci, Neurol Sect, I-44100 Ferrara, Italy

[4] Univ Ferrara, Dept Med Sci, Sect Microbiol & Med Genet, I-44100 Ferrara, Italy

来源：

MULTIPLE SCLEROSIS JOURNAL | 2016年 / 22卷 / 02期

关键词：

Multiple Sclerosis; HLA-G; dimeric form; CSF levels; MRI activity; G MOLECULES; CSF; CELLS;

D O I：

10.1177/1352458515590647

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: The relevance of human leukocyte antigen (HLA)-G in dimeric form in multiple sclerosis (MS) is still unknown. Objective: To investigate the contribution of cerebrospinal fluid (CSF) HLA-G dimers in MS pathogenesis. Methods: CSF amounts of 78-kDa HLA-G dimers were measured by western blot analysis in 80 MS relapsing-remitting MS (RRMS) patients and in 81 inflammatory and 70 non-inflammatory controls. Results: CSF amounts of 78kDa HLA-G dimers were more frequent in RRMS than in inflammatory (p<0.01) and non-inflammatory controls (p<0.001) and in magnetic resonance imaging (MRI) inactive than in MRI active RRMS (p<0.00001). Conclusion: Our findings suggest that HLA-G dimers may be implicated in termination of inflammatory response occurring in MS.

引用

页码：245 / 249

页数：5

共 11 条

[1] A homodimeric complex of HLA-G on normal trophoblast cells modulates antigen-presenting cells via LILRB1 [J].

Apps, Richard ;

Gardner, Lucy ;

Sharkey, Andrew M. ;

Holmes, Nick ;

Moffett, Ashley .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2007, 37 (07) :1924-1937

[2] CSF levels of soluble HLA-G and Fas molecules are inversely associated to MRI evidence of disease activity in patients with relapsing-remitting multiple sclerosis [J].

Fainardi, E. ;

Rizzo, R. ;

Melchiorri, L. ;

Stignani, M. ;

Costellozzi, M. ;

Tomborino, C. ;

Paolino, E. ;

Tola, M. R. ;

Granieri, E. ;

Baricordi, O. R. .

MULTIPLE SCLEROSIS JOURNAL, 2008, 14 (04) :446-454

[3] Intrathecal synthesis of soluble HLA-G and HLA-I molecules are reciprocally associated to clinical and MRI activity in patients with multiple sclerosis [J].

Fainardi, E ;

Rizzo, R ;

Melchiorri, L ;

Castellazzi, M ;

Paolino, E ;

Tola, MR ;

Granieri, E ;

Baricordi, OR .

MULTIPLE SCLEROSIS JOURNAL, 2006, 12 (01) :2-12

[4] Presence of detectable levels of soluble HLA-G molecules in CSF of relapsing-remitting multiple sclerosis: relationship with CSF soluble HLA-I and IL-10 concentrations and MRI findings [J].

Fainardi, E ;

Rizzo, R ;

Melchiorri, L ;

Vaghi, L ;

Castellazzi, M ;

Marzola, A ;

Govoni, V ;

Paolino, E ;

Tola, MR ;

Granieri, E ;

Baricordi, OR .

JOURNAL OF NEUROIMMUNOLOGY, 2003, 142 (1-2) :149-158

[5] Soluble HLA-G molecules are released as HLA-G5 and not as soluble HLA-G1 isoforms in CSF of patients with relapsing-remitting Multiple Sclerosis [J].

Fainardi, Enrico ;

Rizzo, Roberta ;

Melchiorri, Loredana ;

Stignani, Marina ;

Castellazzi, Massimiliano ;

Caniatti, Maria Luisa ;

Baldi, Eleonora ;

Tola, Maria Rosaria ;

Granieri, Enrico ;

Baricordi, Avio Roberto .

JOURNAL OF NEUROIMMUNOLOGY, 2007, 192 (1-2) :219-225

[6] Identification of Circulating Nonclassic Human Leukocyte Antigen G (HLA-G)-Like Molecules in Exudates [J].

Gonzalez, Alvaro ;

Alegre, Estibaliz ;

Arroyo, Ainhoa ;

LeMaoult, Joeel ;

Ignacio Echeveste, Jose .

CLINICAL CHEMISTRY, 2011, 57 (07) :1013-1022

[7] Diagnostic Criteria for Multiple Sclerosis: 2010 Revisions to the McDonald Criteria [J].

Polman, Chris H. ;

Reingold, Stephen C. ;

Banwell, Brenda ;

Clanet, Michel ;

Cohen, Jeffrey A. ;

Filippi, Massimo ;

Fujihara, Kazuo ;

Havrdova, Eva ;

Hutchinson, Michael ;

Kappos, Ludwig ;

Lublin, Fred D. ;

Montalban, Xavier ;

O'Connor, Paul ;

Sandberg-Wollheim, Magnhild ;

Thompson, Alan J. ;

Waubant, Emmanuelle ;

Weinshenker, Brian ;

Wolinsky, Jerry S. .

ANNALS OF NEUROLOGY, 2011, 69 (02) :292-302

[8] Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer [J].

Shiroishi, M ;

Kuroki, K ;

Ose, T ;

Rasubala, L ;

Shiratori, I ;

Arase, H ;

Tsumoto, K ;

Kumagai, I ;

Kohda, D ;

Maenaka, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (15) :10439-10447

[9] Consensus definitions and application guidelines for control groups in cerebrospinal fluid biomarker studies in multiple sclerosis [J].

Teunissen, Charlotte ;

Menge, Til ;

Altintas, Ayse ;

Alvarez-Cermeno, Jose C. ;

Bertolotto, Antonio ;

Berven, Frode S. ;

Brundin, Lou ;

Comabella, Manuel ;

Degn, Matilde ;

Deisenhammer, Florian ;

Fazekas, Franz ;

Franciotta, Diego ;

Frederiksen, Jette L. ;

Galimberti, Daniela ;

Gnanapavan, Sharmilee ;

Hegen, Harald ;

Hemmer, Bernhard ;

Hintzen, Rogier ;

Hughes, Steve ;

Iacobaeus, Ellen ;

Kroksveen, Ann C. ;

Kuhle, Jens ;

Richert, John ;

Tumani, Hayrettin ;

Villar, Luisa M. ;

Drulovic, Jelena ;

Dujmovic, Irena ;

Khalil, Michael ;

Bartos, Ales .

MULTIPLE SCLEROSIS JOURNAL, 2013, 19 (13) :1802-1809

[10] Expression of the immune-tolerogenic major histocompatibility molecule HLA-G in multiple sclerosis: implications for CNS immunity [J].

Wiendl, H ;

Feger, U ;

Mittelbronn, M ;

Jack, C ;

Schreiner, B ;

Stadelmann, C ;

Antel, J ;

Brueck, W ;

Meyermann, R ;

Bar-Or, A ;

Kieseier, BC ;

Weller, M .

BRAIN, 2005, 128 :2689-2704

← 1 2 →