The glial glutamate transporter complementary DNA in patients with amyotrophic lateral sclerosis

被引：33
作者：
Meyer, T
Speer, A
Meyer, B
Sitte, W
Kuther, G
Ludolph, AC
机构：
[1] HUMBOLDT UNIV BERLIN,DEPT NEUROL,D-10117 BERLIN,GERMANY
[2] HUMBOLDT UNIV BERLIN,DEPT INTERNAL MED MOL BIOL,D-10117 BERLIN,GERMANY
[3] HANNOVER MED SCH,DEPT NEUROL,HANNOVER,GERMANY
来源：
ANNALS OF NEUROLOGY | 1996年 / 40卷 / 03期
关键词：
D O I：
10.1002/ana.410400317
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Here, we report a mutation screening by single-stranded conformational analysis of the astroglial human brain glutamate transporter (HBGT) II complementary DNA in patients with amyotrophic lateral sclerosis. The conformational analysis data indicate a lack of sequence variations in the HBGT II coding region in 6 patients with amyotrophic lateral sclerosis and the same number of nonneurological control subjects. In both groups, three variants of the HBGT II 5' untranslated region were isolated. We have no evidence that the reported complementary DNA variants are disease specific.
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页码：456 / 459
页数：4
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