A spinal analog of memory reconsolidation enables reversal of hyperalgesia

被引：48

作者：

Bonin, Robert P. ^{[1
]}

De Koninck, Yves ^{[1
,2
]}

机构：

[1] Inst Univ Sante Mentale Quebec, Unite Neurosci Cellulaires & Mol, Quebec City, PQ, Canada

[2] Univ Laval, Dept Psychiat & Neurosci, Quebec City, PQ, Canada

来源：

NATURE NEUROSCIENCE | 2014年 / 17卷 / 08期

基金：

加拿大健康研究院;

关键词：

LONG-TERM POTENTIATION; DORSAL-HORN; CENTRAL SENSITIZATION; PROTEIN-SYNTHESIS; PAIN; MECHANISMS; PATHWAYS; FEAR;

D O I：

10.1038/nn.3758

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Hyperalgesia arising from sensitization of pain relays in the spinal dorsal horn shares many mechanistic and phenotypic parallels with memory formation. We discovered that mechanical hyperalgesia could be rendered labile and reversible in mice after reactivation of spinal pain pathways in a process analogous to memory reconsolidation. These findings reveal a previously unknown regulatory mechanism underlying hyperalgesia and demonstrate the existence of reconsolidation-like processes in a sensory system.

引用

页码：1043 / 1045

页数：3

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