Palladium-catalysed regioselective aroylation and acetoxylation of 3,5-diarylisoxazole via ortho C-H functionalisations

被引：37

作者：

Banerjee, Arghya ^{[1
]}

Bera, Anupam ^{[1
]}

Santra, Sourav Kumar ^{[1
]}

Guin, Srimanta ^{[1
]}

Patel, Bhisma K. ^{[1
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, Assam, India

来源：

RSC ADVANCES | 2014年 / 4卷 / 17期

关键词：

ALPHA-OXOCARBOXYLIC ACIDS; TERT-BUTYL HYDROPEROXIDE; DECARBOXYLATIVE ACYLATION; BOND ACYLATION; ORTHO-HYDROXYLATION; AROMATIC KETONES; DIRECT ARYLATION; ACETANILIDES; ACTIVATION; ALDEHYDES;

D O I：

10.1039/c3ra45403g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The higher directing ability of N over O in 3,5-diarylisoxazole is demonstrated during the construction of CC and C-O bonds. Out of the four ortho sp(2) C-Hs and one internal sp(2) C-H in 3,5-diarylisoxazoles, regioselective aroylation and acetoxylation take place at one of the ortho-C-Hs proximal to the N atom using Pd(OAc)(2) as the catalyst in the presence of suitable oxidants and solvents.

引用

页码：8558 / 8566

页数：9

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