Palladium-catalysed regioselective aroylation and acetoxylation of 3,5-diarylisoxazole via ortho C-H functionalisations

被引：37
作者：
Banerjee, Arghya [1 ]
Bera, Anupam [1 ]
Santra, Sourav Kumar [1 ]
Guin, Srimanta [1 ]
Patel, Bhisma K. [1 ]
机构：
[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, Assam, India
来源：
RSC ADVANCES | 2014年 / 4卷 / 17期
关键词：
ALPHA-OXOCARBOXYLIC ACIDS; TERT-BUTYL HYDROPEROXIDE; DECARBOXYLATIVE ACYLATION; BOND ACYLATION; ORTHO-HYDROXYLATION; AROMATIC KETONES; DIRECT ARYLATION; ACETANILIDES; ACTIVATION; ALDEHYDES;
D O I：
10.1039/c3ra45403g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The higher directing ability of N over O in 3,5-diarylisoxazole is demonstrated during the construction of CC and C-O bonds. Out of the four ortho sp(2) C-Hs and one internal sp(2) C-H in 3,5-diarylisoxazoles, regioselective aroylation and acetoxylation take place at one of the ortho-C-Hs proximal to the N atom using Pd(OAc)(2) as the catalyst in the presence of suitable oxidants and solvents.
引用
收藏
页码：8558 / 8566
页数：9
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