Serum Helicobacter pylori NapA antibody as a potential biomarker for gastric cancer

被引：9

作者：

Liu, Jingjing ^{[1
]}

Liu, Huimin ^{[2
,3
]}

Zhang, Tingting ^{[1
]}

Ren, Xiyun ^{[1
]}

Nadolny, Christina ^{[4
]}

Dong, Xiaoqun ^{[4
]}

Huang, Lina ^{[1
]}

Yuan, Kexin ^{[1
]}

Tian, Wenjing ^{[1
]}

Jia, Yunhe ^{[5
]}

机构：

[1] Harbin Med Univ, Dept Epidemiol, Coll Publ Hlth, Harbin, Heilongjiang Pr, Peoples R China

[2] Harbin Med Univ, Affiliated Hosp 4, Dept Neurol, Harbin 150001, Heilongjiang Pr, Peoples R China

[3] Univ Rhode Isl, Coll Pharm, Dept Neurol, Kingston, RI 02881 USA

[4] Univ Rhode Isl, Coll Pharm, Dept Biomed & Pharmaceut Sci, Kingston, RI 02881 USA

[5] Harbin Med Univ, Affiliated Hosp 3, Dept Colorectal Canc Surg, Harbin 150081, Heilongjiang Pr, Peoples R China

来源：

SCIENTIFIC REPORTS | 2014年 / 4卷

基金：

中国国家自然科学基金;

关键词：

NEUTROPHIL-ACTIVATING PROTEIN; INFECTION; RISK; ERADICATION; PREVALENCE; DIAGNOSIS; ELISA;

D O I：

10.1038/srep04143

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Helicobacter pylori (H. pylori) infection is strongly associated with gastric cancer. However, only a minority of infected individuals ever develop gastric cancer. This risk stratification may be in part due to differences among strains. The relationship between neutrophil-activating protein (NapA) and gastric cancer is unclear. The purpose of this study is to evaluate the significance of NapA as a biomarker in gastric cancer. We used enzyme linked immunosorbent assay (ELISA) to determine the status of H. pylori infection. Indirect ELISA method was used for detection of NapA antibody titer in the serum of H. pylori infected individuals. Unconditional logistic regressions were adopted to analyze the variables and determine the association of NapA and gastric cancer. The results of study indicated serum H. pylori NapA antibody level were associated with a reduced risk for development of gastric cancer. It may be used in conjugation with other indicators for gastric cancer detection.

引用

页数：5

共 34 条

[1]

Abdullah Shahla M, 2012, Arab J Gastroenterol, V13, P166, DOI 10.1016/j.ajg.2012.12.001

[2] Prevention of Gastric Cancer by Helicobacter pylori Eradication [J].

Asaka, Masahiro ;

Kato, Mototsugu ;

Graham, David Y. .

INTERNAL MEDICINE, 2010, 49 (07) :633-636

[3] Significance of Helicobacter pylori infection as a risk factor in gastric cancer: Serological and histological studies [J].

BarretoZuniga, R ;

Maruyama, M ;

Kato, Y ;

Aizu, K ;

Ohta, H ;

Takekoshi, T ;

Bernal, SF .

JOURNAL OF GASTROENTEROLOGY, 1997, 32 (03) :289-294

[4] Helicobacter pylori neutrophil activating protein as target for new drugs against H. pylori inflammation [J].

Choli-Papadopoulou, Theodora ;

Kottakis, Filippos ;

Papadopoulos, Georgios ;

Pendas, Stefanos .

WORLD JOURNAL OF GASTROENTEROLOGY, 2011, 17 (21) :2585-2591

[5] Upregulation of plasma C9 protein in gastric cancer patients [J].

Chong, Poh-Kuan ;

Lee, Huiyin ;

Loh, Marie Chiew Shia ;

Choong, Lee-Yee ;

Lin, Qingsong ;

So, Jimmy Bok Yan ;

Lim, Khong Hee ;

Soo, Ross Andrew ;

Yong, Wei Peng ;

Chan, Siew Pang ;

Smoot, Duane T. ;

Ashktorab, Hassan ;

Yeoh, Khay Guan ;

Lim, Yoon Pin .

PROTEOMICS, 2010, 10 (18) :3210-3221

[6] H. pylori infection and gastric cancer: State of the art (Review) [J].

Conteduca, Vincenza ;

Sansonno, Domenico ;

Lauletta, Gianfranco ;

Russi, Sabino ;

Ingravallo, Giuseppe ;

Dammacco, Franco .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2013, 42 (01) :5-18

[7] The neutrophil-activating protein of Helicobacter pylori (HP-NAP) as an immune modulating agent [J].

D'Elios, Mario Milco ;

Amedei, Amedeo ;

Cappon, Andrea ;

Del Prete, Gianfranco ;

de Bernard, Marina .

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2007, 50 (02) :157-164

[8]

Dundon WG, 2002, INT J MED MICROBIOL, V291, P545

[9] Meta-analysis: Can Helicobacter pylori Eradication Treatment Reduce the Risk for Gastric Cancer? [J].

Fuccio, Lorenzo ;

Zagari, Rocco Maurizio ;

Eusebi, Leonardo Henry ;

Laterza, Liboria ;

Cennamo, Vincenzo ;

Ceroni, Liza ;

Grilli, Diego ;

Bazzoli, Franco .

ANNALS OF INTERNAL MEDICINE, 2009, 151 (02) :121-W32

[10] Helicobacter pylori Infection and Gastric Cancer Risk: Evaluation of 15 H. pylori Proteins Determined by Novel Multiplex Serology [J].

Gao, Lei ;

Michel, Angelika ;

Weck, Melanie N. ;

Arndt, Volker ;

Pawlita, Michael ;

Brenner, Hermann .

CANCER RESEARCH, 2009, 69 (15) :6164-6170

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