Investigation of Nanodrug Phospholipovit by Small-Angle Neutron Scattering

被引：1
|
作者：
Kiselev, M. A. [1 ,2 ,7 ]
Selyakov, D. N. [1 ,2 ]
Gapon, I. V. [1 ,3 ]
Ivankov, A. I. [1 ,3 ]
Ipatova, O. M. [4 ]
Aksenov, V. L. [1 ,2 ,5 ]
Avdeev, M. V. [1 ,6 ]
机构：
[1] Joint Inst Nucl Res, Dubna 141980, Moscow Oblast, Russia
[2] Moscow MV Lomonosov State Univ, Moscow, Russia
[3] Taras Shevchenko Natl Univ Kyiv, Kiev, Ukraine
[4] Russian Acad Sci, VN Orekhovich Inst Biomed Chem, Moscow 119435, Russia
[5] Natl Res Ctr, Kurchatov Inst, Moscow 123182, Russia
[6] St Petersburg State Univ, St Petersburg 199034, Russia
[7] State Univ Dubna, Dubna 141982, Moscow Oblast, Russia
来源：
CRYSTALLOGRAPHY REPORTS | 2019年 / 64卷 / 04期
基金：
俄罗斯基础研究基金会;
关键词：
D O I：
10.1134/S1063774519040114
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
The structure of aqueous solutions of the Phospholipovit medicine, intended for transport of water-insoluble molecular drugs, has been investigated by small-angle neutron scattering. Phospholipovit can also be used alone, for example, in case of acute poisoning. When processing experimental data, neutron reflectometry was additionally applied to determine the scattering characteristics of maltose buffer solutions in which the medicine is stored. It is shown that Phospholipovit forms temperature-resistant (in the range of 20-37 degrees C) vesicles of critically small size, with inner radius (similar to 40 angstrom) comparable with lipid bilayer thickness (similar to 31 angstrom), in these solutions. The sensitivity of vesicle parameters to an increase in the medicine concentration in solution (up to 25 wt %) and the character of vesicle interaction (indicating the presence of a significant charge on their outer surface) are determined.
引用
收藏
页码：656 / 661
页数：6
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