A review of methotrexate-associated hepatotoxicity

被引：138

作者：

Bath, Roopjeet K. ^{[1
]}

Brar, Navkiran K. ^{[2
]}

Forouhar, Faripour A. ^{[3
]}

Wu, George Y. ^{[1
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Div Gastroenterol & Hepatol, Dept Med, Farmington, CT 06032 USA

[2] Univ Connecticut, Ctr Hlth, Dept Med, Farmington, CT 06032 USA

[3] Univ Connecticut, Ctr Hlth, Dept Anat Pathol, Farmington, CT 06032 USA

来源：

JOURNAL OF DIGESTIVE DISEASES | 2014年 / 15卷 / 10期

关键词：

methotrexate; hepatotoxicity; monitoring; INFLAMMATORY-BOWEL-DISEASE; LONG-TERM METHOTREXATE; HIGH-DOSE METHOTREXATE; RHEUMATOID-ARTHRITIS; LIVER BIOPSIES; PSORIATIC-ARTHRITIS; REAPPRAISAL; TOXICITY; FIBROSIS; THERAPY;

D O I：

10.1111/1751-2980.12184

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Methotrexate is effective not only in treating psoriasis and rheumatoid arthritis but also various other disorders. The use of methotrexate has been somewhat limited by concerns regarding its adverse effects, including its potential for hepatotoxicity. The purpose of this article is to provide an overview of methotrexate-associated hepatotoxicity, including risk factors, pathogenesis and recommendations for monitoring it by US, UK and European guidelines, as well as providing a brief overview of its mechanism of action and of high-dose methotrexate.

引用

页码：517 / 524

页数：8

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