Synthesis and Antimicrobial Activity of Cyclohexane-Containing Mannich Bases Derived from Secondary Amines

被引：1

作者：

Mammadbayli, E. H. ^{[1
]}

Ismayilova, S. V. ^{[1
]}

Hajiyeva, G. A. ^{[1
]}

Jafarova, N. A. ^{[2
]}

Suleymanova, E. I. ^{[2
]}

机构：

[1] Natl Acad Sci Azerbaijan, Inst Petrochem Proc, Baku 1025, Azerbaijan

[2] Azerbaijan State Univ Oil & Ind, Baku 1010, Azerbaijan

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 58卷 / 10期

关键词：

cyclohexanol; secondary amines; Mannich bases; antimicrobial activity;

D O I：

10.1134/S1070428022100062

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New Mannich bases were synthesized from cyclohexanol, formaldehyde, and secondary amines such as piperidine, morpholine, azepane, diethylamine, dipropylamine, dibutylamine, and dihexylamine. The reactions were carried out with equimolar amounts of the reactants in benzene at 78-80 & DEG;C for 4-5 h, and the yields ranged from 63 to 80%. The synthesized compounds were characterized by physical constants, IR, H-1 and C-13 NMR, and mass spectra, and elemental analyses. Their antimicrobial activity was evaluated against gram-positive and gram-negative bacteria (S. aureus, E. coli, P. aeruginosa, K. pneumoniae) and yeast-like fungus of the genus Candida. The results of antimicrobial screening made it possible to recommend the obtained Mannich bases for the design of new antimicrobial agents.

引用

页码：1423 / 1428

页数：6

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