Predictive markers of radiotherapy-induced rectal cancer regression

被引：13

作者：

Shin, J-S ^{[1
,2
,3
]}

Tut, T-G ^{[2
,3
]}

Ho, V. ^{[4
,5
,6
]}

Lee, C. S. ^{[1
,2
,3
]}

机构：

[1] Univ Western Sydney, Liverpool Hosp, Dept Anat Pathol, Liverpool Bc, NSW, Australia

[2] Univ Western Sydney, Ingham Inst Appl Med Res, Canc Pathol & Cell Biol Lab, Liverpool Bc, NSW, Australia

[3] Univ Western Sydney, Disciplines Pathol, Liverpool Bc, NSW, Australia

[4] Univ Western Sydney, Campbelltown Hosp, Dept Gastroenterol, Liverpool Bc, NSW, Australia

[5] Univ Western Sydney, Sch Med, Dept Med, Liverpool Bc, NSW, Australia

[6] Univ Western Sydney, Mol Med Res Grp, Liverpool Bc, NSW, Australia

来源：

JOURNAL OF CLINICAL PATHOLOGY | 2014年 / 67卷 / 10期

关键词：

TERM PREOPERATIVE RADIOTHERAPY; TOTAL MESORECTAL EXCISION; DNA-DAMAGE RESPONSE; TUMOR-REGRESSION; MICROSATELLITE INSTABILITY; ATAXIA-TELANGIECTASIA; MISMATCH REPAIR; IRRADIATED PATIENTS; MRE11; EXPRESSION; PROGNOSTIC VALUE;

D O I：

10.1136/jclinpath-2014-202494

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Patients with locally advanced rectal cancer receive preoperative radiotherapy to reduce the probability of recurrence and to possibly improve overall survival. However, this appears dependent on the extent of histological tumour regression seen in the resected bowel, which can be highly variable between individuals. No predictive marker that can stratify patient management in this regard is currently available. Experimental data implicates a variety of factors that are involved in the DNA damage response following radiation injury, tumour tissue oxygenation, autoimmune antitumour response triggered by radiotherapy and in the pathogenesis of colorectal cancer, as potential indicators of radiation sensitivity. These details are presented in this review, which may serve as targets for clinical validation studies aiming to find predictors of radiotherapy response in rectal cancer.

引用

页码：859 / 864

页数：6

共 78 条

[1]

[Anonymous], AUSTR CANC INC MORT

[2] Preoperative radiotherapy (RT) for rectal cancer: Predictive factors of tumor downstaging and residual tumor cell density (RTCD): Prognostic implications [J].