Facile Preparation of Core-Shell Magnetic Metal-Organic Framework Nanospheres for the Selective Enrichment of Endogenous Peptides

被引：74

作者：

Xiong, Zhichao ^{[1
,2
]}

Ji, Yongsheng ^{[2
,3
]}

Fang, Chunli ^{[2
]}

Zhang, Quanqing ^{[2
]}

Zhang, Lingyi ^{[1
]}

Ye, Mingliang ^{[2
]}

Zhang, Weibing ^{[1
,2
]}

Zou, Hanfa ^{[2
]}

机构：

[1] E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Dept Chem & Mol Engn, Shanghai 200237, Peoples R China

[2] Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China

[3] Henan Univ Tradit Chinese Med, Coll Pharm, Zhengzhou 450008, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 24期

关键词：

core-shell structures; magnetic properties; metal-organic frameworks; nanoparticles; peptides; MESOPOROUS SILICA MICROSPHERES; TOF MS ANALYSIS; MASS-SPECTROMETRY; CHROMATOGRAPHIC-SEPARATION; BIOMEDICAL APPLICATIONS; NANOPARTICLES DESIGN; SIO2; SHELL; SERUM; HYBRID; EXTRACTION;

D O I：

10.1002/chem.201400389

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Facile preparation of core-shell magnetic metal-organic framework nanospheres by a layer-by-layer approach is presented. The nanospheres have high surface area (285.89 cm(2)g(-1)), large pore volume (0.18 cm(3)g(-1)), two kinds of mesopores (2.50 and 4.72 nm), excellent magnetic responsivity (55.65 emu g(-1)), structural stability, and good dispersibility. The combination of porosity, hydrophobicity, and uniform magnetism was exploited for effective enrichment of peptides with simultaneous exclusion of high molecular weight proteins. The nanospheres were successfully applied in the selective enrichment of endogenous peptides in human serum.

引用

页码：7389 / 7395

页数：7

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