Selective functionalization of mesoporous silica nanoparticles with ibuprofen and Gd(III) chelates: a new probe for potential theranostic applications

被引:17
作者
Carniato, Fabio [1 ]
Munoz-Ubeda, Monica [1 ]
Tei, Lorenzo [1 ]
Botta, Mauro [1 ]
机构
[1] Univ Piemonte Orientale, Dipartimento Sci & Innovaz Tecnol, I-15121 Alessandria, Italy
关键词
MAGNETIC-RESONANCE RELAXATION; MODEL-FREE APPROACH; CHEMICAL STRATEGY; MACROMOLECULES; SURFACE;
D O I
10.1039/c5dt03144c
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Organo-modified mesoporous silica nanoparticles, loaded with ibuprofen into the pores and functionalized on the external surface with a stable Gd(III)-DOTA-monoamide chelate, were prepared and explored as potential theranostic probes.
引用
收藏
页码:17927 / 17931
页数:5
相关论文
共 23 条
[1]   Mesoporous Silica Nanoparticles: Selective Surface Functionalization for Optimal Relaxometric and Drug Loading Performances [J].
Bouchoucha, Meryem ;
C-Gaudreault, Rene ;
Fortin, Marc-Andre ;
Kleitz, Freddy .
ADVANCED FUNCTIONAL MATERIALS, 2014, 24 (37) :5911-5923
[2]   Selective Anchoring of GdIII Chelates on the External Surface of Organo-Modified Mesoporous Silica Nanoparticles: A New Chemical Strategy To Enhance Relaxivity [J].
Carniato, Fabio ;
Tei, Lorenzo ;
Arrais, Aldo ;
Marchese, Leonardo ;
Botta, Mauro .
CHEMISTRY-A EUROPEAN JOURNAL, 2013, 19 (04) :1421-1428
[3]   A Chemical Strategy for the Relaxivity Enhancement of GdIII Chelates Anchored on Mesoporous Silica Nanoparticles [J].
Carniato, Fabio ;
Tei, Lorenzo ;
Cossi, Maurizio ;
Marchese, Leonardo ;
Botta, Mauro .
CHEMISTRY-A EUROPEAN JOURNAL, 2010, 16 (35) :10727-10734
[4]   Relaxivity modulation in Gd-functionalised mesoporous silicas [J].
Carniato, Fabio ;
Tei, Lorenzo ;
Dastru, Walter ;
Marchese, Leonardo ;
Botta, Mauro .
CHEMICAL COMMUNICATIONS, 2009, (10) :1246-1248
[5]   Study of nanobiomaterial hydroxyapatite in simulated body fluid: Formation and growth of apatite [J].
Chavan, Pradnya N. ;
Bahir, Manjushri M. ;
Mene, Ravindra U. ;
Mahabole, Megha P. ;
Khairnar, Rajendra S. .
MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS, 2010, 168 (1-3) :224-230
[6]   In Vivo Bio-Safety Evaluations and Diagnostic/Therapeutic Applications of Chemically Designed Mesoporous Silica Nanoparticles [J].
Chen, Yu ;
Chen, Hangrong ;
Shi, Jianlin .
ADVANCED MATERIALS, 2013, 25 (23) :3144-3176
[7]   Non-metallic nanomaterials in cancer theranostics: a review of silica- and carbon-based drug delivery systems [J].
Chen, Yu-Cheng ;
Huang, Xin-Chun ;
Luo, Yun-Ling ;
Chang, Yung-Chen ;
Hsieh, You-Zung ;
Hsu, Hsin-Yun .
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS, 2013, 14 (04)
[8]   In vitro and in vivo magnetic resonance detection of tumor cells by targeting glutamine transporters with Gd-based probes [J].
Geninatti Crich, Simonetta ;
Cabella, Claudia ;
Barge, Alessandro ;
Belfiore, Simona ;
Ghirelli, Cristina ;
Lattuada, Luciano ;
Lanzardo, Stefania ;
Mortillaro, Armando ;
Tei, Lorenzo ;
Visigalli, Massimo ;
Forni, Guido ;
Aime, Silvio .
JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (16) :4926-4936
[9]   Mesoporous silica nanoparticles as a delivery system of gadolinium for effective human stem cell tracking [J].
Hsiao, Jong-Kai ;
Tsai, Chih-Pin ;
Chung, Tsai-Hua ;
Hung, Yann ;
Yao, Ming ;
Liu, Hon-Man ;
Mou, Chung-Yuan ;
Yang, Chung-Shi ;
Chen, Yao-Chang ;
Huang, Dong-Ming .
SMALL, 2008, 4 (09) :1445-1452
[10]   Grain size control of mesoporous silica and formation of bimodal pore structures [J].
Ikari, K ;
Suzuki, K ;
Imai, H .
LANGMUIR, 2004, 20 (26) :11504-11508