Transcranial magnetic stimulation of mouse brain using high-resolution anatomical models

被引：19

作者：

Crowther, L. J. ^{[1
]}

Hadimani, R. L. ^{[1
]}

Kanthasamy, A. G. ^{[2
]}

Jiles, D. C. ^{[1
]}

机构：

[1] Iowa State Univ, Dept Elect & Comp Engn, Ames, IA 50011 USA

[2] Iowa State Univ, Dept Biomed Sci, Ames, IA 50011 USA

来源：

JOURNAL OF APPLIED PHYSICS | 2014年 / 115卷 / 17期

关键词：

DIELECTRIC-PROPERTIES; BIOLOGICAL TISSUES;

D O I：

10.1063/1.4862217

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Transcranial magnetic stimulation (TMS) offers the possibility of non-invasive treatment of brain disorders in humans. Studies on animals can allow rapid progress of the research including exploring a variety of different treatment conditions. Numerical calculations using animal models are needed to help design suitable TMS coils for use in animal experiments, in particular, to estimate the electric field induced in animal brains. In this paper, we have implemented a high-resolution anatomical MRI-derived mouse model consisting of 50 tissue types to accurately calculate induced electric field in the mouse brain. Magnetic field measurements have been performed on the surface of the coil and compared with the calculations in order to validate the calculated magnetic and induced electric fields in the brain. Results show how the induced electric field is distributed in a mouse brain and allow investigation of how this could be improved for TMS studies using mice. The findings have important implications in further preclinical development of TMS for treatment of human diseases. (C) 2014 AIP Publishing LLC.

引用

页数：3

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