The pentose phosphate pathway and cancer

被引：1077

作者：

Patra, Krushna C. ^{[1
]}

Hay, Nissim ^{[2
,3
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Canc, Boston, MA 02114 USA

[2] Univ Illinois, Coll Med, Dept Biochem & Mol Genet, Chicago, IL 60607 USA

[3] Jesse Brown VA Med Ctr, Res & Dev Sect, Chicago, IL 60612 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2014年 / 39卷 / 08期

基金：

美国国家卫生研究院;

关键词：

6-PHOSPHOGLUCONATE DEHYDROGENASE; ADRIAMYCIN RESISTANCE; GLYCOLYTIC-ENZYMES; CELL-PROLIFERATION; GLUCOSE-METABOLISM; ENDOTHELIAL-CELLS; LEUKEMIA-CELLS; TUMOR-CELLS; GLUCOSE-6-PHOSPHATE-DEHYDROGENASE; TRANSKETOLASE;

D O I：

10.1016/j.tibs.2014.06.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The pentose phosphate pathway (PPP), which branches from glycolysis at the first committed step of glucose metabolism, is required for the synthesis of ribonucleotides and is a major source of NADPH. NADPH is required for and consumed during fatty acid synthesis and the scavenging of reactive oxygen species (ROS). Therefore, the PPP plays a pivotal role in helping glycolytic cancer cells to meet their anabolic demands and combat oxidative stress. Recently, several neoplastic lesions were shown to have evolved to facilitate the flux of glucose into the PPP. This review summarizes the fundamental functions of the PPP, its regulation in cancer cells, and its importance in cancer cell metabolism and survival.

引用

页码：347 / 354

页数：8

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