Classification, Epidemiology, and Genetics of Orofacial Clefts

被引：158
作者：
Watkins, Stephanie E. [1 ]
Meyer, Robert E. [2 ]
Strauss, Ronald P. [3 ]
Aylsworth, Arthur S. [4 ,5 ]
机构：
[1] Univ N Carolina, Ctr Hlth Promot & Dis Prevent, Chapel Hill, NC 27514 USA
[2] State Ctr Hlth Stat, North Carolina Dept Hlth & Human Serv, Div Publ Hlth, Birth Defects Monitoring Program, Raleigh, NC 27603 USA
[3] Univ N Carolina, UNC Sch Med, UNC Sch Dent, UNC Ctr AIDS Res, Chapel Hill, NC 27599 USA
[4] Univ N Carolina, Dept Pediat, Chapel Hill, NC 27599 USA
[5] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA
来源：
CLINICS IN PLASTIC SURGERY | 2014年 / 41卷 / 02期
关键词：
Epidemiology; Orofacial clefts; Classification; Genetics; MATERNAL CIGARETTE-SMOKING; GENOME-WIDE ASSOCIATION; PIERRE ROBIN-SEQUENCE; PERICONCEPTIONAL ALCOHOL-CONSUMPTION; BIRTH-DEFECTS PREVENTION; POPULATION-BASED SAMPLE; ORIS MUSCLE DEFECTS; ORAL CLEFTS; FOLIC-ACID; INFANT CHARACTERISTICS;
D O I：
10.1016/j.cps.2013.12.003
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Orofacial clefts (OFCs) include a broad range of facial conditions that differ in cause and disease burden. In the published literature, there is substantial ambiguity in both terminology and classification of OFCs. This article discusses the terminology and classification of OFCs and the epidemiology of OFCs. Demographic, environmental, and genetic risk factors for OFCs are described, including suggestions for family counseling. This article enables clinicians to counsel families regarding the occurrence and recurrence of OFCs. Although much of the information is detailed, it is intended to be accessible to all health professionals for use in their clinical practices.
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页码：149 / +
页数：16
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