Renal denervation for the treatment of resistant hypertension in Spain. The Flex-Spyral Registry

Introduction and objectives: Renal denervation is a percutaneous intervention for the treatment of resistant hypertension. Randomized studies have shown contradictory results on its efficacy. We present the results of a renal denervation registry for the treatment of resistant hypertension in real-life patients in Spain. Methods: Multicenter registry of consecutive patients with resistant hypertension treated with renal denervation in Spain between 2009 and 2018. Results: We included 125 patients (mean age, 56 years; 41% female; mean onset of hypertension 14 +/- 9 years previously). Office systolic and diastolic blood pressure and ambulatory blood pressure monitoring decreased 6 months after the intervention (166 +/- 20/95 +/- 16 to 149 +/- 22/87 +/- 16 mmHg and 151 +/- 14/89 +/- 12 to 143 +/- 15/84 +/- 11, both P < .0001). At 12 months, the blood pressure reduction was maintained and the number of antihypertensive drugs decreased from 4.9 +/- 1.2 to 4.4 +/- 1.5 (P = .0001). There were no significant procedure-related complications. The response rate to denervation at 1 year was 80%, but there were wide differences between centers. Conclusions: In patients with resistant hypertension, treatment with renal denervation was related to a decrease in office blood pressure and, more importantly, in ambulatory blood pressure monitoring, with a significant reduction in pharmacological treatment. (C) 2019 Published by Elsevier Espana, S.L.U. on behalf of Sociedad Espanola de Cardiologia.