Polycomb Repression under the Skin

被引：2
作者：
Pirrotta, Vincenzo [1 ]
机构：
[1] Rutgers State Univ, Dept Mol Biol & Biochem, Piscataway, NJ 08854 USA
来源：
CELL | 2009年 / 136卷 / 06期
关键词：
EMBRYONIC STEM-CELLS; GENES; METHYLATION;
D O I：
10.1016/j.cell.2009.03.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Polycomb group proteins control a hierarchy of gene expression during the differentiation of stem cells. In this issue, Ezhkova et al. (2009) show that repression mediated by Polycomb proteins controls the timing of differentiation of precursor cells of the epidermal lineage.
引用
收藏
页码：992 / 994
页数：4
相关论文
共 8 条
  • [1] A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    Bernstein, BE
    Mikkelsen, TS
    Xie, XH
    Kamal, M
    Huebert, DJ
    Cuff, J
    Fry, B
    Meissner, A
    Wernig, M
    Plath, K
    Jaenisch, R
    Wagschal, A
    Feil, R
    Schreiber, SL
    Lander, ES
    [J]. CELL, 2006, 125 (02) : 315 - 326
  • [2] Polycomb complexes repress developmental regulators in murine embryonic stem cells
    Boyer, LA
    Plath, K
    Zeitlinger, J
    Brambrink, T
    Medeiros, LA
    Lee, TI
    Levine, SS
    Wernig, M
    Tajonar, A
    Ray, MK
    Bell, GW
    Otte, AP
    Vidal, M
    Gifford, DK
    Young, RA
    Jaenisch, R
    [J]. NATURE, 2006, 441 (7091) : 349 - 353
  • [3] De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes
    Epsztejn-Litman, Silvina
    Feldman, Nirit
    Abu-Remaileh, Monther
    Shufaro, Yoel
    Gerson, Ariela
    Ueda, Jun
    Deplus, Rachel
    Fuks, Francois
    Shinkai, Yoichi
    Cedar, Howard
    Bergman, Yehudit
    [J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2008, 15 (11) : 1176 - 1183
  • [4] G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis
    Feldman, N
    Gerson, A
    Fang, J
    Li, E
    Zhang, Y
    Shinkai, Y
    Cedar, H
    Bergman, Y
    [J]. NATURE CELL BIOLOGY, 2006, 8 (02) : 188 - U55
  • [5] The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation
    Montgomery, ND
    Yee, D
    Chen, A
    Kalantry, S
    Chamberlain, SJ
    Otte, AP
    Magnuson, T
    [J]. CURRENT BIOLOGY, 2005, 15 (10) : 942 - 947
  • [6] The Polycomb-group gene Ezh2 is required for early mouse development
    O'Carroll, D
    Erhardt, S
    Pagani, M
    Barton, SC
    Surani, MA
    Jenuwein, T
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (13) : 4330 - 4336
  • [7] The polycomb group protein Suz12 is required for embryonic stem cell differentiation
    Pasini, Diego
    Bracken, Adrian P.
    Hansen, Jacob B.
    Capillo, Manuela
    Helin, Kristian
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (10) : 3769 - 3779
  • [8] Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells
    Stock, Julie K.
    Giadrossi, Sara
    Casanova, Miguel
    Brookes, Emily
    Vidal, Miguel
    Koseki, Haruhiko
    Brockdorff, Neil
    Fisher, Amanda G.
    Pombo, Ana
    [J]. NATURE CELL BIOLOGY, 2007, 9 (12) : 1428 - U174
1