Structural Abnormalities in the Dyslexic Brain: A Meta-Analysis of Voxel-Based Morphometry Studies

被引：172

作者：

Richlan, Fabio ^{[1
,2
]}

Kronbichler, Martin ^{[1
,2
,3
,4
]}

Wimmer, Heinz ^{[1
,2
]}

机构：

[1] Salzburg Univ, Dept Psychol, A-5020 Salzburg, Austria

[2] Salzburg Univ, Ctr Neurocognit Res, A-5020 Salzburg, Austria

[3] Paracelsus Private Med Univ, Christian Doppler Clin, Inst Neurosci, Salzburg, Austria

[4] Paracelsus Private Med Univ, Christian Doppler Clin, Dept Neurol, Salzburg, Austria

来源：

HUMAN BRAIN MAPPING | 2013年 / 34卷 / 11期

基金：

奥地利科学基金会;

关键词：

dyslexia; reading; magnetic resonance imaging; meta-analysis; cerebral cortex; GRAY-MATTER VOLUME; WHITE-MATTER; DEVELOPMENTAL DYSLEXIA; INDIVIDUAL-DIFFERENCES; READING-ABILITY; NEURAL SYSTEMS; CHILDREN; CONNECTIVITY; MICROSTRUCTURE; DIFFUSIVITY;

D O I：

10.1002/hbm.22127

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We used coordinate-based meta-analysis in order to objectively quantify gray matter abnormalities reported in nine Voxel-Based Morphometry studies of developmental dyslexia. Consistently across studies, reduced gray matter volume in dyslexic readers was found in the right superior temporal gyrus and left superior temporal sulcus. These results were related to findings from previous meta-analyses on functional brain abnormalities in dyslexic readers. Convergence of gray matter reduction and reading-related underactivation was found for the left superior temporal sulcus. Recent studies point to the presence of both functional and structural abnormalities in left temporal and occipito-temporal brain regions before reading onset. Hum Brain Mapp 34:3055-3065, 2013. (c) 2012 Wiley Periodicals, Inc.

引用

页码：3055 / 3065

页数：11

共 87 条

[1] Voxel-based morphometry - The methods [J].