A NEUROSURGEON'S GUIDE TO STEM CELLS, CANCER STEM CELLS, AND BRAIN TUMOR STEM CELLS

被引：44

作者：

Cheshier, Samuel H. ^{[1
,2
]}

Kalani, M. Yashar S. ^{[1
,2
]}

Lim, Michael ^{[3
]}

Ailles, Laurie

Huhn, Steven L. ^{[4
]}

Weissman, Irving L. ^{[2
]}

机构：

[1] Stanford Univ, Sch Med, Stanford Inst Stem Cell Biol & Regenerat Med, Dept Neurosurg, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Stanford Inst Stem Cell Biol & Regenerat Med, Dept Dev Biol, Stanford, CA 94305 USA

[3] Johns Hopkins Univ Hosp, Dept Neurosurg, Baltimore, MD 21287 USA

[4] Stem Cells Inc, Palo Alto, CA USA

来源：

NEUROSURGERY | 2009年 / 65卷 / 02期

关键词：

Brain tumor; Brain tumor stem cell; Cancer stem cell; Stem cell; ACUTE MYELOGENOUS LEUKEMIA; ACUTE MYELOID-LEUKEMIA; EMBRYONIC HUMAN CNS; HEMATOPOIETIC STEM; SUBVENTRICULAR ZONE; NERVOUS-SYSTEM; SELF-RENEWAL; SPINAL-CORD; GROWTH-CHARACTERISTICS; NEURAL PRECURSORS;

D O I：

10.1227/01.NEU.0000349921.14519.2A

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

STEM CELLS AND their potential applications have become the forefront of scientific, political, and ethical discourse. Whereas stem cells were long accepted as units of development and evolution, it is now becoming increasingly clear that they are also units of oncogenesis. Although the field of stem cell biology is expanding at an astounding rate, the data attained are not readily translatable for the physicians who may eventually deliver these tools to patients. Herein, we provide a brief review of stem cell and cancer stem cell biology and highlight the scientific and clinical implications of recent findings regarding the presence of cancer-forming stem cells in brain tumors.

引用

页码：237 / 249

页数：13

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