Recurrent Medullary Thyroid Carcinoma on 68Ga-Prostate-Specific Membrane Antigen PET/CT: Exploring New Theranostic Avenues

被引：20

作者：

Arora, Saurabh ^{[1
]}

Damle, Nishikant Avinash ^{[1
]}

Parida, Girish Kumar ^{[1
]}

Singhal, Abhinav ^{[1
]}

Nalli, Harish ^{[1
]}

Dattagupta, Shreya ^{[1
]}

Bal, Chandrasekar ^{[1
]}

机构：

[1] All India Inst Med Sci, Dept Nucl Med, New Delhi 110029, India

来源：

CLINICAL NUCLEAR MEDICINE | 2018年 / 43卷 / 05期

关键词：

medullary thyroid carcinoma; PET; CT; prostate-specific membrane antigen (PSMA); PSMA EXPRESSION; GA-68-PSMA PET/CT;

D O I：

10.1097/RLU.0000000000002010

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer cells. Few other malignancies have shown expression of PSMA. We present a case of 35-year-old man with medullary thyroid carcinoma, post total thyroidectomy and bilateral neck dissection, now presenting with rising calcitonin levels (doubling time 9 months) and local neck recurrence with negative I-131-MIBG scan. We decided to perform Ga-68-PSMA-HBED-CC PET/CT scan to assess PSMA expression and explore the therapeutic option in view of rising serum calcitonin. It revealed intense PSMA uptake in the soft tissue mass in left thyroid bed and cervical lymph nodes.

引用

页码：359 / 360

页数：2

共 11 条

[1]

Chang SS, 1999, CANCER RES, V59, P3192

[2] Unusual Uptake of Prostate Specific Tracer 68Ga-PSMA–HBED-CC in a Benign Thyroid Nodule [J].

Damle N.A. ;

Tripathi M. ;

Chakraborty P.S. ;

Sahoo M.K. ;

Bal C. ;

Aggarwal S. ;

Arora G. ;

Kumar P. ;

Kumar R. ;

Gupta R. .

Nuclear Medicine and Molecular Imaging, 2016, 50 (4) :344-347

[3] Rectal Carcinoma on 68Ga-PSMA PET/CT [J].

Huang, Yi-Tung Tom ;

Fong, William ;

Thomas, Paul .

CLINICAL NUCLEAR MEDICINE, 2016, 41 (03) :E167-E168

[4] Follicular Lymphoma Showing Avid Uptake on 68Ga PSMA-HBED-CC PET/CT [J].

Kanthan, Gowri L. ;

Coyle, Luke ;

Kneebone, Andrew ;

Schembri, Geoffrey Paul ;

Hsiao, Edward .

CLINICAL NUCLEAR MEDICINE, 2016, 41 (06) :500-501

[5] Prospective Comparison of 18F-Fluoromethylcholine Versus 68Ga-PSMA PET/CT in Prostate Cancer Patients Who Have Rising PSA After Curative Treatment and Are Being Considered for Targeted Therapy [J].

Morigi, Joshua J. ;

Stricker, Phillip D. ;

van Leeuwen, Pim J. ;

Tang, Reuben ;

Ho, Bao ;

Quoc Nguyen ;

Hruby, George ;

Fogarty, Gerald ;

Jagavkar, Raj ;

Kneebone, Andrew ;

Hickey, Adam ;

Fanti, Stefano ;

Tarlinton, Lisa ;

Emmett, Louise .

JOURNAL OF NUCLEAR MEDICINE, 2015, 56 (08) :1185-1190

[6] Upregulation of prostate specific membrane antigen/folate hydrolase transcription by an enhancer [J].

Noss, KR ;

Wolfe, SA ;

Grimes, SR .

GENE, 2002, 285 (1-2) :247-256

[7] Elevated 68Ga Prostate-Specific Membrane Antigen Activity in Metastatic Non-Small Cell Lung Cancer [J].

Shetty, Deepa ;

Loh, Han ;

Bui, Chuong ;

Mansberg, Robert ;

Stevanovic, Amanda .

CLINICAL NUCLEAR MEDICINE, 2016, 41 (05) :414-416

[8] PSMA Expression in Papillary Thyroid Carcinoma: Opening a New Horizon in Management of Thyroid Cancer? [J].

Taywade, Sameer Kamalakar ;

Damle, Nishikant Avinash ;

Bal, Chandrasekhar .

CLINICAL NUCLEAR MEDICINE, 2016, 41 (05) :E263-E265

[9] Prostate-Specific Membrane Antigen (PSMA) Avid Pancreatic Neuroendocrine Tumor [J].

Vamadevan, Shankar ;

Shetty, Deepa ;

Le, Ken ;

Bui, Chuong ;

Mansberg, Robert ;

Loh, Han .

CLINICAL NUCLEAR MEDICINE, 2016, 41 (10) :804-806

[10] First evidence of PSMA expression in differentiated thyroid cancer using [68Ga]PSMA-HBED-CC PET/CT [J].

Verburg, Frederik A. ;

Krohn, Thomas ;

Heinzel, Alexander ;

Mottaghy, Felix M. ;

Behrendt, Florian F. .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2015, 42 (10) :1622-1623

← 1 2 →