Kumada Cross-Coupling of Aryl Grignard Reagents with Aryl Halides Catalyzed by an Immobilized Nickel Catalyst

被引：8

作者：

Chen, Xiaofang ^{[1
]}

Wang, Lei ^{[1
,2
]}

Liu, Jie ^{[1
]}

机构：

[1] Huaibei Coal Teachers Coll, Dept Chem, Huaibei 235000, Anhui, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2009年 / 14期

关键词：

Kumada cross-coupling; immobilized nickel(II) complex; bidentate nitrogen ligands; Grignard reagents; aryl halides; INORGANIC HYBRID MATERIALS; CARBON-CARBON BONDS; REUSABLE CATALYST; HIGHLY EFFICIENT; HETEROGENEOUS CATALYST; ON-CHARCOAL; C-C; PALLADIUM; SILICA; SONOGASHIRA;

D O I：

10.1055/s-0029-1216832

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Kumada cross-coupling reaction of a variety of unactivated aryl bromides and aryl chlorides with phenylmagnesium bromide has been developed. The reaction is catalyzed by an immobilized nickel(II) complex containing a pyrrolidine unit, which is part of a bidentate nitrogen ligand. The catalyst is highly efficient for the Kumada reaction, which proceeds smoothly at 10 degrees C to generate the corresponding products in good to excellent yields. In addition, the catalyst can be reused five times without significant loss of activity.

引用

页码：2408 / 2412

页数：5

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