Novel silyl linkers for solid-phase synthesis

被引：10

作者：

Meloni, MM

Brown, RCD ^{[1
]}

White, PD

Armour, D

机构：

[1] Univ Southampton, Dept Chem, Ctr Combinatorial Chem, Southampton SO17 1BJ, Hants, England

[2] CN Biosci UK Ltd, Novabiochem, Beeston NG9 2JR, England

[3] Pfizer Global Res & Dev, Sandwich CT13 9NJ, Kent, England

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 34期

关键词：

D O I：

10.1016/S0040-4039(02)01213-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The syntheses of two silyl chloride resins, 2 and 10 are described starting from Merrifield resin, 3-methyl-1,3-butanediol and diphenyldichlorosilane or dimethyldichlorosilane, respectively. The silyl chloride resin 2 was used for the attachment of V alcohols, 2degrees alcohols and phenols to the solid phase. A preliminary study of the stability of the diphenylsiloxane linker towards certain reaction conditions was also carried out. A more reactive silyl chloride resin 10 was found to be suitable for the attachment of 3degrees alcohols to the solid-phase. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：6023 / 6026

页数：4

共 27 条

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