Incidence, clinical, risk factors and outcomes of Guillain-Barre in Covid-19

被引：83

作者：

Fragiel, Marcos ^{[1
]}

Miro, Oscar ^{[2
]}

Llorens, Pere ^{[3
]}

Jimenez, Sonia ^{[2
]}

Pinera, Pascual ^{[4
]}

Burillo, Guillermo ^{[5
]}

Martin, Alfonso ^{[6
]}

Martin-Sanchez, Francisco J. ^{[1
]}

Garcia-Lamberechts, Eric J. ^{[1
]}

Jacob, Javier ^{[7
]}

Alquezar-Arbe, Aitor ^{[8
]}

Juarez, Ricardo ^{[9
]}

Jimenez, Blas ^{[10
]}

Del Rio, Rigoberto ^{[11
]}

Mateo Roca, Miriam ^{[8
]}

Garcia, Arturo H. ^{[12
]}

Lopez Laguna, Nieves ^{[13
]}

Lopez Diez, Maria P. ^{[14
]}

Pedraza Garcia, Jorge ^{[15
]}

de Simon Almela, Amparo Fernandez ^{[16
]}

Lopez Diaz, Juan J. ^{[17
]}

Eiroa Hernandez, Patricia ^{[18
]}

Ruiz de Lobera, Noemi ^{[19
]}

Porta-Etessam, Jesus ^{[20
]}

Fernandez Perez, Cristina ^{[21
]}

CaIvo, Elpidio ^{[22
]}

Gonzalez del Castillo, Juan ^{[1
]}

机构：

[1] Univ Complutense Madrid, San Carlos Clin Hosp, Inst Invest Sanitaria San Carlos, Emergency Dept, Madrid, Spain

[2] Univ Barcelona, Clin Hosp, Inst Invest Biomed August Pi i Sunyer, Emergency Dept, Barcelona, Spain

[3] Miguel Hernandez Univ, Alicante Gen Hosp, Emergency Dept, Alicante, Spain

[4] Reina Sofia Hosp, Emergency Dept, Murcia, Spain

[5] Univ Hosp Canary Isl, Emergency Dept, Tenerife, Spain

[6] Severo Ochoa Hosp, Emergency Dept, Madrid, Spain

[7] Bellvitge Univ Hosp, Emergency Dept, Barcelona, Spain

[8] Hosp Holy Cross & St Paul, Emergency Dept, Barcelona, Spain

[9] Our Lady Prado Hosp Talavera de la Reina, Emergency Dept, Toledo, Spain

[10] Vinalopo Elche Univ Hosp, Emergency Dept, Alicante, Spain

[11] Univ Hosp Torrevieja Alicante, Emergency Dept, Alicante, Spain

[12] Sacred Family Clin, Emergency Dept, Barcelona, Spain

[13] Navarra Univ Clin Madrid, Emergency Dept, Madrid, Spain

[14] Burgos Univ Hosp, Emergency Dept, Burgos, Spain

[15] Los Pedroches Valley Reg Hosp, Emergency Dept, Cordoba, Spain

[16] Virgin Rocio Hosp Seville, Emergency Dept, Seville, Spain

[17] Lucus Augusti Lugo Univ Hosp, Emergency Dept, Lugo, Spain

[18] Canary Isl Univ Hosp, Emergency Dept, Tenerife, Spain

[19] San Pedro Hosp Logrono, Emergency Dept, Logrono, Spain

[20] San Carlos Clin Hosp, Neurol Dept, Madrid, Spain

[21] Santiago de Compostela Hosp Complex, Prevent Med Dept, La Coruna, Spain

[22] Univ Complutense Madrid, San Carlos Clin Hosp, Inst Invest Sanitaria San Carlos, Internal Med Dept, Madrid, Spain

来源：

ANNALS OF NEUROLOGY | 2021年 / 89卷 / 03期

关键词：

D O I：

10.1002/ana.25987

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We diagnosed 11 Guillain-Barre syndrome (GBS) cases among 71,904 COVID patients attended at 61 Spanish emergency departments (EDs) during the 2-month pandemic peak. The relative frequency of GBS among ED patients was higher in COVID (0.15 parts per thousand) than non-COVID (0.02 parts per thousand) patients (odds ratio [OR] = 6.30, 95% confidence interval [CI] = 3.18-12.5), as was the standardized incidence (9.44 and 0.69 cases/100,000 inhabitant-years, respectively, OR = 13.5, 95% CI = 9.87-18.4). Regarding clinical characteristics, olfactory-gustatory disorders were more frequent in COVID-GBS than non-COVID-GBS (OR = 27.59, 95% CI = 1.296-587) and COVID-non-GBS (OR = 7.875, 95% CI = 1.587-39.09) patients. Although COVID-GBS patients were more frequently admitted to intensive care, mortality was not increased versus control groups. Our results suggest SARS-CoV-2 could be another viral infection causing GBS. ANN NEUROL 2020

引用

页码：598 / 603

页数：6

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