CCK biosynthesis and processing: Recent progress and future challenges

被引：26
作者：
Beinfeld, MC
机构：
来源：
LIFE SCIENCES | 1997年 / 61卷 / 24期
关键词：
CCK; PC1; PC2; post-translational modification of proteins; tyrosine sulfation; carboxypeptidase;
D O I：
10.1016/S0024-3205(97)00644-9
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The peptide cholecystokinin (CCK), like other peptides which pass through the regulated secretory pathway, undergoes a number of post-translational modifications during its biosynthesis including tyrosine sulfation, endoproteolytic cleavage, and trimming by carboxypeptidases. This minireview summarizes what is known about this process in endocrine cells and in the Cpe(fat)/Cpe(fat) mouse and points out what challenges remain for future research.
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收藏
页码：2359 / 2366
页数：8
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