Horizon scanning for translational genomic research beyond bench to bedside

被引：23

作者：

Clyne, Mindy ^{[1
,2
]}

Schully, Sheri D. ^{[2
]}

Dotson, W. David ^{[3
]}

Douglas, Michael P. ^{[3
,4
]}

Gwinn, Marta ^{[3
,4
]}

Kolor, Katherine ^{[3
]}

Wulf, Anja ^{[3
,5
]}

Bowen, M. Scott ^{[3
]}

Khoury, Muin J. ^{[2
,3
]}

机构：

[1] Kelly Serv, Troy, MI 48084 USA

[2] NCI, Epidemiol & Genom Res Program, Bethesda, MD 20892 USA

[3] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA USA

[4] McKing Consulting Corp, Atlanta, GA USA

[5] Cadence Grp, Atlanta, GA USA

来源：

GENETICS IN MEDICINE | 2014年 / 16卷 / 07期

关键词：

genomic medicine; horizon scanning; public health; surveillance; translational research; MEDICINE; UTILITY; DISEASE; FUTURE; TESTS;

D O I：

10.1038/gim.2013.184

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Purpose: The dizzying pace of genomic discoveries is leading to an increasing number of clinical applications. In this report, we provide a method for horizon scanning and 1 year data on translational research beyond bench to bedside to assess the validity, utility, implementation, and outcomes of such applications. Methods: We compiled cross-sectional results of ongoing horizon scanning of translational genomic research, conducted between 16 May 2012 and 15 May 2013, based on a weekly, systematic query of PubMed. A set of 505 beyond bench to bedside articles were collected and classified, including 312 original research articles; 123 systematic and other reviews; 38 clinical guidelines, policies, and recommendations; and 32 articles describing tools, decision support, and educational materials. Results: Most articles (62%) addressed a specific genomic test or other health application; almost half of these (n = 180) were related to cancer. We estimate that these publications account for 0.5% of reported human genomics and genetics research during the same time. Conclusion: These data provide baseline information to track the evolving knowledge base and gaps in genomic medicine. Continuous horizon scanning of the translational genomics literature is crucial for an evidence-based translation of genomics discoveries into improved health care and disease prevention.

引用

页码：535 / 538

页数：4

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