Cigarette Smoking and Pancreatic Cancer: A Pooled Analysis From the Pancreatic Cancer Cohort Consortium

被引：248

作者：

Lynch, Shannon M. ^{[1
]}

Vrieling, Alina ^{[2
]}

Lubin, Jay H. ^{[3
]}

Kraft, Peter ^{[4
]}

Mendelsohn, Julie B. ^{[3
]}

Hartge, Patricia ^{[3
]}

Canzian, Federico ^{[5
]}

Steplowski, Emily ^{[6
]}

Arslan, Alan A. ^{[7
,8
]}

Gross, Myron ^{[9
]}

Helzlsouer, Kathy ^{[10
]}

Jacobs, Eric J. ^{[11
]}

LaCroix, Andrea ^{[12
]}

Petersen, Gloria ^{[13
]}

Zheng, Wei ^{[14
]}

Albanes, Demetrius ^{[3
]}

Amundadottir, Laufey ^{[3
]}

Bingham, Sheila A. ^{[15
]}

Boffetta, Paolo ^{[16
]}

Boutron-Ruault, Marie-Christine ^{[17
,18
]}

Chanock, Stephen J. ^{[3
]}

Clipp, Sandra ^{[19
]}

Hoover, Robert N. ^{[3
]}

Jacobs, Kevin ^{[3
,20
,21
]}

Johnson, Karen C. ^{[22
]}

Kooperberg, Charles ^{[12
]}

Luo, Juhua ^{[23
]}

Messina, Catherine ^{[24
]}

Palli, Domenico ^{[25
]}

Patel, Alpa V. ^{[11
]}

Riboli, Elio ^{[26
]}

Shu, Xiao-Ou ^{[14
]}

Rodriguez Suarez, Laudina ^{[27
]}

Thomas, Gilles ^{[3
]}

Tjonneland, Anne ^{[28
]}

Tobias, Geoffrey S. ^{[3
]}

Tong, Elissa ^{[29
]}

Trichopoulos, Dimitrios ^{[4
,30
]}

Virtamo, Jarmo ^{[31
]}

Ye, Weimin ^{[16
]}

Yu, Kai ^{[3
]}

Zeleniuch-Jacquette, Anne ^{[7
,8
]}

Bueno-de-Mesquita, H. Bas ^{[2
]}

Stolzenberg-Solomon, Rachael Z. ^{[3
]}

机构：

[1] NCI, Epidemiol & Genet Res Program, Div Canc Control & Populat Sci, NIH,Dept Hlth & Human Serv, Rockville, MD USA

[2] Natl Inst Publ Hlth & Environm, RIVM, NL-3720 BA Bilthoven, Netherlands

[3] NCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Rockville, MD USA

[4] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[5] German Canc Res Ctr, D-6900 Heidelberg, Germany

[6] Informat Management Serv Inc, Rockville, MD USA

[7] NYU, Sch Med, Dept Environm Med, New York, NY USA

[8] NYU, Sch Med, Inst Canc, New York, NY USA

[9] Univ Minnesota, Sch Med, Dept Lab Med Pathol, Prevent Res Ctr, Minneapolis, MN 55455 USA

[10] St Johns Mercy Med Ctr, Prevent & Res Ctr, Baltimore, MD USA

[11] Amer Canc Soc, Dept Epidemiol & Surveillance Res, Atlanta, GA 30329 USA

[12] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA

[13] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA

[14] Vanderbilt Univ, Dept Med, Vanderbilt Ingram Canc Ctr, Nashville, TN USA

[15] Univ Cambridge, Ctr Nutr & Canc, MRC, Cambridge, England

[16] Int Agcy Res Canc, F-69372 Lyon, France

[17] INSERM, Villejuif, France

[18] Inst Gustave Roussy, Villejuif, France

[19] George W Comstock Ctr Publ Hlth Res & Prevent, Hagerstown, MD USA

[20] Bioinformed Consulting Serv, Gaithersburg, MD USA

[21] SAIC Frederick Inc, Natl Canc Inst Frederick, Adv Technol Program, Core Genotyping Facil, Frederick, MD USA

[22] Univ Tennessee, Hlth Sci Ctr, Dept Prevent Med, Memphis, TN USA

[23] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[24] SUNY Stony Brook, Dept Prevent Med, Stony Brook, NY 11794 USA

[25] ISPP, Canc Res & Prevent Inst, Mol & Nutr Epidemiol Unit, Florence, Italy

[26] Univ London Imperial Coll Sci Technol & Med, Div Epidemiol Publ Hlth & Primary Care, London, England

[27] Hlth & Hlth Care Serv Council, Publ Hlth Directorate, Asturias, Spain

[28] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[29] Univ Calif Davis, Div Gen Internal Med, Davis, CA 95616 USA

[30] Univ Athens, Sch Med, Dept Hyg & Epidemiol, Athens, Greece

[31] Natl Publ Hlth Inst, Dept Hlth Promot & Chron Dis Prevent, Helsinki, Finland

来源：

AMERICAN JOURNAL OF EPIDEMIOLOGY | 2009年 / 170卷 / 04期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

pancreas; pancreatic neoplasms; smoking; tobacco use cessation; MODELING TOTAL EXPOSURE; LUNG-CANCER; RISK-FACTORS; METAANALYSIS; INTENSITY; TRIAL; MEN; PREVENTION; SHANGHAI; PATTERNS;

D O I：

10.1093/aje/kwp134

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Smoking is an established risk factor for pancreatic cancer; however, detailed examination of the association of smoking intensity, smoking duration, and cumulative smoking dose with pancreatic cancer is limited. The authors analyzed pooled data from the international Pancreatic Cancer Cohort Consortium nested case-control study (1,481 cases, 1,539 controls). Odds ratios and 95% confidence intervals were calculated by using unconditional logistic regression. Smoking intensity effects were examined with an excess odds ratio model that was linear in pack-years and exponential in cigarettes smoked per day and its square. When compared with never smokers, current smokers had a significantly elevated risk (odds ratio (OR) = 1.77, 95% confidence interval (CI): 1.38, 2.26). Risk increased significantly with greater intensity (>= 30 cigarettes/day: OR = 1.75, 95% CI: 1.27, 2.42), duration (>= 50 years: OR = 2.13, 95% CI: 1.25, 3.62), and cumulative smoking dose (>= 40 pack-years: OR = 1.78, 95% CI: 1.35, 2.34). Risk more than 15 years after smoking cessation was similar to that for never smokers. Estimates of excess odds ratio per pack-year declined with increasing intensity, suggesting greater risk for total exposure delivered at lower intensity for longer duration than for higher intensity for shorter duration. This finding and the decline in risk after smoking cessation suggest that smoking has a late-stage effect on pancreatic carcinogenesis.

引用

页码：403 / 413

页数：11

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