The Ras branch of small GTPases: Ras family members don't fall far from the tree

被引：342
作者：
Reuther, GW [1 ]
Der, CJ [1 ]
机构：
[1] Univ N Carolina, Sch Med, Lineberger Comprehens Canc Ctr, Dept Pharmacol, Chapel Hill, NC 27599 USA
来源：
CURRENT OPINION IN CELL BIOLOGY | 2000年 / 12卷 / 02期
关键词：
D O I：
10.1016/S0955-0674(99)00071-X
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The Ras branch of the Ras superfamily consists of small GTPases most closely related to Ras and include the R-Ras, Rap, Ral, Rheb, Rin and Rit proteins. Although our understanding of Ras signaling and biology is now considerable, recent observations suggest that Ras function is more complex than previously believed. First, the three Ras proteins may not be functionally identical. Second, Ras function involves functional cross-talk with their close relatives.
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页码：157 / 165
页数：9
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