Selective Intermolecular Amination of C-H Bonds at Tertiary Carbon Centers

被引：114
|
作者：
Roizen, Jennifer L. [2 ]
Zalatan, David N. [1 ]
Du Bois, J. [1 ]
机构：
[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA
[2] Duke Univ, Dept Chem, Durham, NC 27708 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 43期
基金：
美国国家科学基金会;
关键词：
amination; amines; C-H insertion; isotope effect; rhodium; MEMANTINE HYDROCHLORIDE; EFFICIENT SYNTHESIS; CATALYST; HYDROCARBONS; OXIDATION; POSITION; ALKANES; AZIDES;
D O I：
10.1002/anie.201304238
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
C-H insertion: A method for intermolecular amination of tertiary C-H bonds is described that uses limiting amounts of substrate and a convenient phenol-derived nitrogen source. Structure-selectivity and mechanistic studies suggest that steric interaction between the substrate and active oxidant is the principal determinant of product selectivity. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：11343 / 11346
页数：4
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