Topical drug delivery systems: a patent review

被引:133
作者
Malik, Deepinder Singh [1 ]
Mital, Neeraj [1 ]
Kaur, Gurpreet [1 ]
机构
[1] Punjabi Univ, Dept Pharmaceut Sci & Drug Res, Patiala, Punjab, India
关键词
topical delivery; sustained release; Hydrogels; nano-carriers; LOCALIZED TREATMENT; NASAL; FORMULATION; MUCOADHESIVE; NANOPARTICLES; GEL; STRATEGIES; LIPOSOMES; HYDROGELS; CARRIERS;
D O I
10.1517/13543776.2016.1131267
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Introduction: Topical administration is the favored route for local delivery of therapeutic agents due to its convenience and affordability. The specific challenge of designing a therapeutic system is to achieve an optimal concentration of a certain drug at its site of action for an appropriate duration. Areas covered: This review summarizes innovations from the past 3years (2012-2015) in the field of topical drug delivery for the treatment of local infections of the vagina, nose, eye and skin. The review also throws some light on the anatomy and physiology of these organs and their various defensive barriers which affect the delivery of drugs administered topically. Expert opinion: Topical administration has been gaining attention over the last few years. However, conventional topical drug delivery systems suffer from drawbacks such as poor retention and low bioavailability. The successful formulation of topical delivery products requires the careful manipulation of defensive barriers and selection of a soluble drug carrier. Extensive research is required to develop newer topical drug delivery systems aiming either to improve the efficacy or to reduce side effects compared to current patented systems.
引用
收藏
页码:213 / 228
页数:16
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