ACE2 Expression in Kidney and Testis May Cause Kidney and Testis Infection in COVID-19 Patients

被引:128
作者
Fan, Caibin [1 ]
Lu, Wei [2 ]
Li, Kai [1 ]
Ding, Yanhong [1 ]
Wang, Jianqing [1 ]
机构
[1] Nanjing Med Univ, Affiliated Suzhou Hosp, Dept Urol, Nanjing, Peoples R China
[2] Suzhou Vocat Hlth Coll, Sch Nursing, Suzhou, Peoples R China
基金
中国国家自然科学基金;
关键词
COVID-19; SARS-Cov-2; kidney; testis; ACE2; CELLS;
D O I
10.3389/fmed.2020.563893
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In December 2019, a new type of pneumonia caused by SARS-Cov-2 (COVID-19) occurred in Wuhan and has been discovered in many countries around the world. ACE2 (angiotensin-converting enzyme 2) has been shown to be one of the major receptors that mediate the entry of SARS-Cov-2 into human cells. Here in this study, we used the online datasets to analyze ACE2 expression in different human organs. The results indicated that ACE2 highly expresses in renal tubular cells, Sertoli cells, Leydig cells, and cells in seminiferous ducts in testis. Recombinant SARS-CoV-2 spike protein (RBD) domain and ACE2 of RPTEC/SerC cell-binding assays confirmed that SARS-Cov-2 can bind to ACE2 on the surface of these cells. Our results suggest that ACE2 expression could contribute to kidney and testis infection after COVID-19 infection. Renal function evaluation and special care should be performed during clinical work. Clinicians should also pay attention to the risk of testicular lesions in patients during hospitalization and later clinical follow-up, especially the assessment and appropriate intervention in young patients' fertility.
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收藏
页数:9
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