Magnetic resonance T1w/T2w ratio in the middle cerebellar peduncle might be a sensitive biomarker for multiple system atrophy

被引：8

作者：

Sugiyama, Atsuhiko ^{[1
]}

Yokota, Hajime ^{[2
]}

Hirano, Shigeki ^{[1
]}

Cooper, Graham ^{[3
,4
,5
,6
,7
,8
,9
,10
]}

Mukai, Hiroki ^{[2
]}

Koide, Kyosuke ^{[1
]}

Wang, Jiaqi ^{[1
]}

Ito, Shoichi ^{[1
,11
]}

Finke, Carsten ^{[8
,12
,13
]}

Brandt, Alexander U. ^{[7
,14
]}

Paul, Friedemann ^{[3
,4
,5
,6
,7
,8
,12
]}

Kuwabara, Satoshi ^{[1
]}

机构：

[1] Chiba Univ, Dept Neurol, Grad Sch Med, Chuo Ku, 1-8-1 Inohana, Chiba 2608677, Japan

[2] Chiba Univ, Grad Sch Med, Dept Diagnost Radiol & Radiat Oncol, Chiba, Japan

[3] Humboldt Univ, Expt & Clin Res Ctr, Max Delbrueck Ctr Mol Med, Berlin, Germany

[4] Charite Univ Med Berlin, Berlin, Germany

[5] Free Univ Berlin, Humboldt Univ Berlin, Berlin, Germany

[6] Berlin Inst Hlth, Berlin, Germany

[7] Charite Univ Med Berlin, NeuroCure Clin Res Ctr, Berlin, Germany

[8] Einstein Ctr Neurosci, Berlin, Germany

[9] Charite Univ Med Berlin, Dept Expt Neurol, Berlin, Germany

[10] Charite Univ Med Berlin, Ctr Stroke Res, Berlin, Germany

[11] Chiba Univ, Grad Sch Med, Dept Med Educ, Chiba, Japan

[12] Charite Univ Med Berlin, Dept Neurol, Berlin, Germany

[13] Humboldt Univ, Berlin Sch Mind & Brain, Berlin, Germany

[14] Univ Calif Irvine, Dept Neurol, Irvine, CA 92717 USA

来源：

EUROPEAN RADIOLOGY | 2021年 / 31卷 / 06期

关键词：

Magnetic resonance imaging; Cerebellar ataxia; Middle cerebellar peduncle; Multiple system atrophy; MYELIN CONTENT; DIAGNOSIS; MR; CRITERIA; PHENOTYPE; CORTEX; MSA;

D O I：

10.1007/s00330-020-07521-1

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Objective We aimed to investigate the use of a myelin-sensitive MRI contrast, the standardized T1-weighted/T2-weighted (sT1w/T2w) ratio, for detecting early changes in the middle cerebellar peduncle (MCP) in cerebellar subtype multiple system atrophy (MSA-C) patients. Methods We included 28 MSA-C patients, including a subset of 17 MSA-C patients within 2 years of disease onset (early MSA-C), and 28 matched healthy controls. T1w and T2w scans were acquired using a 3-T MR system. The sT1w/T2w ratio in MCP was analyzed using SPM12 by utilizing a region-of-interest approach in normalized space. The diagnostic performance of the MCP sT1w/T2w ratio in discriminating MSA-C and the subgroup of early MSA-C from the matched controls was assessed. Correlation analyses were performed to evaluate the relationship between the MCP sT1w/T2w ratio and other clinical parameters including the International Cooperative Ataxia Scale (ICARS) score for quantifying cerebellar ataxia. Results Compared to controls, the sT1w/T2w ratio in the MCP was markedly lower in all (p < 0.001) MSA-C patients and 17 early (p < 0.001) MSA-C patients. The MCP sT1w/T2w ratio had high sensitivity (96%) and specificity (100%) to distinguish MSA-C from controls (area under the curve = 0.99), even for the early MSA-C group (area under the curve = 0.99; sensitivity = 94%, specificity = 100%). The MCP sT1w/T2w ratio correlated with the ICARS score in early MSA-C. Conclusions The sT1w/T2w ratio can detect MSA-C-related changes in the MCP, even in the early stages of the disorder, and could be a sensitive biomarker for MSA-C.

引用

页码：4277 / 4284

页数：8

共 31 条

[31] Relationship Between Pituitary Adenoma Consistency and Extent of Resection Based on Tumor/Cerebellar Peduncle T2-Weighted Imaging Intensity (TCTI) Ratio of the Point on Preoperative Magnetic Resonance Imaging (MRI) Corresponding to the Residual Point on Postoperative MRI
Chen, Xiao-Yong
Ding, Chen-Yu
You, Hong-Hai
Chen, Jin-Yuan
Jiang, Chang-Zhen
Yan, Xiao-Rong
Lin, Zhang-Ya
Kang, De-Zhi
MEDICAL SCIENCE MONITOR, 2020, 26

← 1 2 3 4 →