Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort

被引：22

作者：

Fortner, Renee T. ^{[1
]}

Sarink, Danja ^{[1
]}

Schock, Helena ^{[1
]}

Johnson, Theron ^{[1
]}

Tjonneland, Anne ^{[2
]}

Olsen, Anja ^{[2
]}

Overvad, Kim ^{[3
]}

Affret, Aurelie ^{[4
,5
]}

His, Mathilde ^{[4
,5
]}

Boutron-Ruault, Marie-Christine ^{[4
,5
]}

Boeing, Heiner ^{[6
]}

Trichopoulou, Antonia ^{[7
,8
]}

Naska, Androniki ^{[7
,8
]}

Orfanos, Philippos ^{[7
,8
]}

Palli, Domenico ^{[9
]}

Sieri, Sabina ^{[10
]}

Mattiello, Amalia ^{[11
]}

Tumino, Rosario ^{[12
]}

Ricceri, Fulvio ^{[13
,14
]}

Bueno-de-Mesquita, H. Bas ^{[15
,16
,17
]}

Peeters, Petra H. M. ^{[18
,19
]}

Van Gils, Carla H. ^{[18
]}

Weiderpass, Elisabete ^{[20
,21
,22
,23
]}

Lund, Eiliv ^{[20
]}

Quiros, J. Ramon ^{[24
]}

Agudo, Antonio ^{[25
]}

Sanchez, Maria-Jose ^{[26
,27
]}

Chirlaque, Maria-Dolores ^{[27
,28
,29
]}

Ardanaz, Eva ^{[27
,30
,31
]}

Dorronsoro, Miren ^{[32
,33
]}

Key, Tim ^{[34
]}

Khaw, Kay-Tee ^{[35
]}

Rinaldi, Sabina ^{[36
]}

Dossus, Laure ^{[36
]}

Gunter, Marc ^{[36
]}

Merritt, Melissa A. ^{[16
]}

Riboli, Elio ^{[16
]}

Kaaks, Rudolf ^{[1
]}

机构：

[1] German Canc Res Ctr, Div Canc Epidemiol, Neuenheimer Feld 280, D-69120 Heidelberg, Germany

[2] Danish Canc Soc Res Ctr, Diet Genes & Environm, Copenhagen, Denmark

[3] Aarhus Univ, Epidemiol Sect, Dept Publ Hlth, Aarhus, Denmark

[4] Univ Paris Sud, Univ Paris Saclay, UVSQ, CESP,INSERM, Villejuif, France

[5] Gustave Roussy, F-94805 Villejuif, France

[6] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[7] Hellen Hlth Fdn, Athens, Greece

[8] Univ Athens, WHO Collaborating Ctr Nutr & Hlth, Unit Nutr Epidemiol & Nutr Publ Hlth, Dept Hyg Epidemiol & Med Stat,Med Sch, Athens, Greece

[9] Canc Res & Prevent Inst ISPO, Canc Risk Factors & Life Style Epidemiol Unit, Florence, Italy

[10] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Dept Prevent & Predict Med, Milan, Italy

[11] Univ Naples Federico II, Dipartimento Med Clin & Chirurg, Naples, Italy

[12] Civ Mp Arezzo Hosp, Canc Registry & Histopathol Unit, Asp Ragusa, Italy

[13] Reg Hlth Serv ASL TO3, Epidemiol Unit, Grugliasco, TO, Italy

[14] Univ Turin, Dept Med Sci, Unit Canc Epidemiol, Turin, Italy

[15] Natl Inst Publ Hlth & Environm RIVM, Dept Determinants Chron Dis DCD, Bilthoven, Netherlands

[16] Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London, England

[17] Univ Malaya, Dept Social & Prevent Med, Fac Med, Kuala Lumpur, Malaysia

[18] Univ Med Ctr Utrecht, Dept Epidemiol, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[19] Imperial Coll, MRC PHE Ctr Environm & Hlth, Dept Epidemiol & Biostat, Sch Publ Hlth, London, England

[20] Arctic Univ Norway, Dept Community Med, Fac Hlth Sci, Univ Tromso, Tromso, Norway

[21] Canc Registry Norway, Inst Populat Based Canc Res, Dept Res, Oslo, Norway

[22] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[23] Folkhalsan Res Ctr, Genet Epidemiol Grp, Helsinki, Finland

[24] Publ Hlth Directorate, Asturias, Spain

[25] Catalan Inst Oncol IDIBELL, Unit Nutr & Canc, Canc Epidemiol Res Program, Barcelona, Spain

[26] Univ Granada, Escuela Andaluza Salud Publ, Inst Invest Biosanitaria Ibs, Hosp Univ Granada, Granada, Spain

[27] CIBERESP, Madrid, Spain

[28] IMIB Arrixaca, Dept Epidemiol, Reg Hlth Council, Murcia, Spain

[29] Univ Murcia, Dept Hlth & Social Sci, Murcia, Spain

[30] Navarra Publ Hlth Inst, Pamplona, Spain

[31] Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain

[32] Basque Reg Hlth Dept, Publ Hlth Direct, San Sebastian, Spain

[33] Basque Reg Hlth Dept, Biodonostia Res Inst CIBERESP, San Sebastian, Spain

[34] Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England

[35] Univ Cambridge, Canc Epidemiol Unit, Cambridge, England

[36] Int Agcy Res Canc, Lyon, France

来源：

BMC MEDICINE | 2017年 / 15卷

基金：

英国医学研究理事会; 瑞典研究理事会;

关键词：

Breast cancer; Osteoprotegerin; RANK axis; Hormone receptor; Estrogen receptor; Progesterone receptor; FACTOR-KAPPA-B; LIGAND RANKL; OSTEOCLAST DIFFERENTIATION; CIRCULATING OSTEOPROTEGERIN; SERUM OSTEOPROTEGERIN; POSTMENOPAUSAL WOMEN; GENERAL-POPULATION; EXPRESSION; CELLS; ACTIVATOR;

D O I：

10.1186/s12916-017-0786-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Circulating OPG and breast cancer risk has been examined in only one prior study. Methods: A case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 2008 incident invasive breast cancer cases (estrogen receptor (ER)+, n = 1622; ER-, n = 386), matched 1: 1 to controls, were included in the analysis. Women were predominantly postmenopausal at blood collection (77%); postmenopausal women included users and non-users of postmenopausal hormone therapy (HT). Serum OPG was quantified with an electrochemiluminescence assay. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Results: The associations between OPG and ER+ and ER-breast cancer differed significantly. Higher concentrations of OPG were associated with increased risk of ER-breast cancer (top vs. bottom tertile RR = 1.93 [95% CI 1.24-3.02]; p(trend) = 0.03). We observed a suggestive inverse association for ER+ disease overall and among women premenopausal at blood collection. Results for ER-disease did not differ by menopausal status at blood collection (p(het) = 0.97), and we observed no heterogeneity by HT use at blood collection (p(het) >= 0.43) or age at breast cancer diagnosis (p(het) >= 0.30). Conclusions: This study provides the first prospective data on OPG and breast cancer risk by hormone receptor subtype. High circulating OPG may represent a novel risk factor for ER-breast cancer.

引用

页数：10

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