Recent advances in the detection of brown adipose tissue in adult humans: a review

被引：50

作者：

Ong, Frank J. ^{[1
]}

Ahmed, Basma A. ^{[2
]}

Oreskovich, Stephan M. ^{[1
]}

Blondin, Denis P. ^{[3
]}

Haq, Tahniyah ^{[1
]}

Konyer, Norman B. ^{[4
]}

Noseworthy, Michael D. ^{[5
]}

Haman, Francois ^{[6
]}

Carpentier, Andre C. ^{[4
]}

Morrison, Katherine M. ^{[1
]}

Steinberg, Gregory R. ^{[2
,7
]}

机构：

[1] McMaster Univ, Dept Pediat, Hamilton, ON, Canada

[2] McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON, Canada

[3] Univ Sherbrooke, Div Endocrinol, Dept Med, Ctr Rech CHUS, Sherbrooke, PQ, Canada

[4] St Josephs Healthcare, Imaging Res Ctr, Hamilton, ON, Canada

[5] McMaster Univ, Dept Elect & Comp Engn, Hamilton, ON, Canada

[6] Univ Ottawa, Sch Human Kinet, 125 Univ St, Ottawa, ON, Canada

[7] McMaster Univ, Div Endocrinol & Metab, Dept Med, Hamilton, ON, Canada

来源：

CLINICAL SCIENCE | 2018年 / 132卷 / 10期

基金：

加拿大健康研究院;

关键词：

COLD-ACTIVATED BROWN; AGE-RELATED-CHANGES; BODY-MASS INDEX; FAT-FRACTION; INSULIN SENSITIVITY; BLOOD-FLOW; INFRARED THERMOGRAPHY; GLUCOSE-UPTAKE; CONTRAST ECHOCARDIOGRAPHY; OXIDATIVE-METABOLISM;

D O I：

10.1042/CS20170276

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The activation of brown adipose tissue (BAT) is associated with reductions in circulating lipids and glucose in rodents and contributes to energy expenditure in humans indicating the potential therapeutic importance of targetting this tissue for the treatment of a variety of metabolic disorders. In order to evaluate the therapeutic potential of human BAT, a variety of methodologies for assessing the volume and metabolic activity of BAT are utilized. Cold exposure is often utilized to increase BAT activity but inconsistencies in the characteristics of the exposure protocols make it challenging to compare findings. The metabolic activity of BAT in response to cold exposure has most commonly been measured by static positron emission tomography of F-18-fluorodeoxyglucose in combination with computed tomography (F-18-FDG PET-CT) imaging, but recent studies suggest that under some conditions this may not always reflect BAT thermogenic activity. Therefore, recent studies have used alternative positron emission tomography and computed tomography (PET-CT) imaging strategies and radiotracers that may offer important insights. In addition to PET-CT, there are numerous emerging techniques that may have utility for assessing BAT metabolic activity including magnetic resonance imaging (MRI), skin temperaturemeasurements, near-infrared spectroscopy (NIRS) and contrast ultrasound (CU). In this review, we discuss and critically evaluate the various methodologies used to measure BAT metabolic activity in humans and provide a contemporary assessment of protocols which may be useful in interpreting research findings and guiding the development of future studies.

引用

页码：1039 / 1054

页数：16

共 145 条

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