Prostate-Specific Antigen and Prostate-Specific Antigen Velocity as Threshold Indicators in 11C-Acetate PET/CTAC Scanning for Prostate Cancer Recurrence

被引:14
作者
Dusing, Reginald W. [1 ]
Peng, Warner [1 ]
Lai, Sue-Min [2 ]
Grado, Gordon L. [3 ]
Holzbeierlein, Jeffrey M. [4 ]
Thrasher, J. Brantley [4 ]
Hill, Jacqueline [1 ]
Van Veldhuizen, Peter J. [5 ]
机构
[1] Univ Kansas, Med Ctr, Dept Radiol, Kansas City, KS 66103 USA
[2] Univ Kansas, Med Ctr, Dept Prevent Med & Publ Hlth, Kansas City, KS 66103 USA
[3] Southwest Oncol Ctr, Scottsdale, AZ USA
[4] Univ Kansas, Med Ctr, Dept Urol, Kansas City, KS 66103 USA
[5] Univ Kansas, Med Ctr, Dept Hematol & Oncol, Kansas City, KS 66103 USA
关键词
C-11-acetate PET; prostate cancer recurrence; prostate cancer imaging; PSA; C-11-choline PET; POSITRON-EMISSION-TOMOGRAPHY; RADICAL PROSTATECTOMY; C-11-CHOLINE PET/CT; BIOCHEMICAL FAILURE; LOCAL RECURRENCE; PSA KINETICS; RADIOTHERAPY; F-18-CHOLINE; DISEASE; RELAPSE;
D O I
10.1097/RLU.0000000000000516
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: The aim of this study was to identify which patient characteristics are associated with the highest likelihood of positive findings on C-11-acetate PET/computed tomography attenuation correction (CTAC) (PET/CTAC) scan when imaging for recurrent prostate cancer. Methods: From 2007 to 2011, 250 C-11-acetate PET/CTAC scans were performed at a single institution on patients with prostate cancer recurrence after surgery, brachytherapy, or external beam radiation. Of these patients, 120 met our inclusion criteria. Logistic regression analysis was used to examine the relationship between predictability of positive findings and patients' characteristics, such as prostate-specific antigen (PSA) level at the time of scan, PSA kinetics, Gleason score, staging, and type of treatment before scan. Results: In total, 68.3% of the 120 C-11-acetate PET/CTAC scans were positive. The percentage of positive scans and PSA at the time of scanning and PSA velocity (PSAV) had positive correlations. The putative sensitivity and specificity were 86.6% and 65.8%, respectively, when a PSA level greater than 1.24 ng/mL was used as the threshold for scanning. The putative sensitivity and specificity were 74% and 75%, respectively, when a PSAV level greater than 1.32 ng/mL/y was used as the threshold. No significant associations were found between scan positivity and age, PSA doubling time, Gleason score, staging, or type of treatment before scanning. Conclusions: This retrospective study suggests that threshold models of PSA greater than 1.24 ng/mL or PSAV greater than 1.32 ng/mL per year are independent predictors of positive findings in C-11-acetate PET/CTAC imaging of recurrent prostate cancer.
引用
收藏
页码:777 / 783
页数:7
相关论文
共 31 条
  • [1] American Joint Committee on Cancer, 2009, PROST CANC STAG
  • [2] [Anonymous], EUR UROL
  • [3] [Anonymous], PROST SPEC ANT BEST
  • [4] [Anonymous], 2014, CANC FACTS FIG 2014
  • [5] [Anonymous], ONCOLOGY WILLISTON P
  • [6] [Anonymous], ONCOLOGY WILLISTON P
  • [7] Radiotherapy for a rising prostate-specific antigen after radical prostatectomy: The first 10 years
    Anscher, MS
    Clough, R
    Dodge, R
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2000, 48 (02): : 369 - 375
  • [8] 18F-Choline, 11C-choline and 11C-acetate PET/CT: comparative analysis for imaging prostate cancer patients
    Brogsitter, Claudia
    Zoephel, Klaus
    Kotzerke, Joerg
    [J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2013, 40 : S18 - S27
  • [9] Influence of Trigger PSA and PSA Kinetics on 11C-Choline PET/CT Detection Rate in Patients with Biochemical Relapse After Radical Prostatectomy
    Castellucci, Paolo
    Fuccio, Chiara
    Nanni, Cristina
    Santi, Ivan
    Rizzello, Anna
    Lodi, Filippo
    Franceschelli, Alessandro
    Martorana, Giuseppe
    Manferrari, Fabio
    Fanti, Stefano
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2009, 50 (09) : 1394 - 1400
  • [10] PREDICTING RADIONUCLIDE BONE-SCAN FINDINGS IN PATIENTS WITH NEWLY DIAGNOSED, UNTREATED PROSTATE-CANCER - PROSTATE SPECIFIC ANTIGEN IS SUPERIOR TO ALL OTHER CLINICAL-PARAMETERS
    CHYBOWSKI, FM
    KELLER, JJL
    BERGSTRALH, EJ
    OESTERLING, JE
    [J]. JOURNAL OF UROLOGY, 1991, 145 (02) : 313 - 318