Organocatalytic Approach for C(sp3)-H Bond Arylation, Alkylation, and Amidation of lsochromans under Facile Conditions

被引：60
|
作者：
Muramatsu, Wataru [1 ]
Nakano, Kimihiro [1 ]
机构：
[1] Nagasaki Univ, Grad Sch Biomed Sci, Nagasaki 8528521, Japan
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 07期
关键词：
C-H BONDS; DIRECT FUNCTIONALIZATION; CYCLIC ETHERS; OXIDATION; 2,3-DICHLORO-5,6-DICYANOHYDROQUINONE; ADJACENT; IRON;
D O I：
10.1021/ol5006399
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new catalytic approach for the synthesis of isochroman derivatives via direct C(sp(3))-H bond arylation is described. The oxidation reaction with [bis(trifluoroacetoxy)-iodo]benzene facilitates the regeneration of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone in the C(sp(3))-H bond arylation of isochroman. The reaction conditions can also be used for alkyl Grignard reagents and amides to afford the corresponding isochroman derivatives.
引用
收藏
页码：2042 / 2045
页数：4
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