Therapeutic potential of olfactory ensheathing cells in neurodegenerative diseases

被引：44
|
作者：
Chiu, Shao-Chih [1 ,2 ]
Hung, Huey-Shan [1 ,5 ]
Lin, Shinn-Zong [1 ,2 ]
Chiang, Esheral [3 ]
Liu, Demeral David [1 ,4 ]
机构：
[1] China Med Univ Hosp, Ctr Neuropsychiat, Taichung 40447, Taiwan
[2] China Med Univ, Grad Inst Immunol, Taichung, Taiwan
[3] Natl Yang Ming Univ, Inst Oral Biol, Taipei 112, Taiwan
[4] China Med Univ Hosp, Oral Biol Lab, Dept Dent, Taichung 40447, Taiwan
[5] China Med Univ, Grad Inst Basic Med Sci, Taichung, Taiwan
来源：
JOURNAL OF MOLECULAR MEDICINE-JMM | 2009年 / 87卷 / 12期
关键词：
Cerebral ischemia; Olfactory ensheathing cells; Neurogenesis; Transplantation; SPINAL-CORD-INJURY; NEURAL STEM-CELLS; CELLULAR PRION PROTEIN; NERVE GROWTH-FACTOR; SCHWANN-CELLS; FUNCTIONAL RECOVERY; IN-VITRO; AXONAL REGENERATION; NEUROTROPHIC FACTOR; PARKINSONS-DISEASE;
D O I：
10.1007/s00109-009-0528-2
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The regenerative capacity of the olfactory system has generated interest in potential clinical application of cells from the olfactory epithelium in the treatment of neurodegenerative diseases. Experimental evidence from animal models and clinical studies suggest that transplantation of olfactory ensheathing cells (OEC), specialized glia in the olfactory system, may be therapeutically useful in neurodegenerative diseases such as spinal cord injury and stroke. This review article describes the different experimental approaches in OEC transplantation. We also discuss the possible effects of OEC implantation on the underlying pathophysiology in neurological disease, including neuroplasticity. Our recent study of this particular population of cells has disclosed some of the molecular basis of the regenerative mechanism of OECs. In summary OECs produce several neurotrophic factors such as stromal cell-derived factor 1 alpha and brain-derived neurotrophic factor and enhance axonal regeneration to promote neuroplasticity in neurodegenerative diseases.
引用
收藏
页码：1179 / 1189
页数：11
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