Pre- and Post-therapy Assessment of Clinical Outcomes and White Matter Integrity in Autism Spectrum Disorder: Pilot Study

被引:15
作者
Saaybi, Stephanie [1 ,2 ]
AlArab, Natally [3 ]
Hannoun, Salem [4 ,5 ]
Saade, Maritherese [6 ]
Tutunji, Rayyan [3 ,7 ]
Zeeni, Carine [8 ]
Shbarou, Rolla [1 ]
Hourani, Roula [3 ]
Boustany, Rose-Mary [1 ,6 ]
机构
[1] Amer Univ Beirut, Dept Pediat & Adolescent Med Biochem & Mol Genet, Div Pediat Neurol, Med Ctr, Beirut, Lebanon
[2] MedStar Georgetown Univ Hosp, Dept Pediat & Adolescent Med, Washington, DC USA
[3] Amer Univ Beirut, Dept Diagnost Radiol, Med Ctr, Div Neuroradiol, Beirut, Lebanon
[4] Amer Univ Beirut, Fac Med, Nehrne & Therese Tohme Multiple Sclerosis Ctr, Med Ctr, Beirut, Lebanon
[5] Amer Univ Beirut, Fac Med, Abu Haidar Neurosci Inst, Med Ctr, Beirut, Lebanon
[6] Amer Univ Beirut, Med Ctr, ASKC, Beirut, Lebanon
[7] Radboud Univ Nijmegen, Donders Inst Brain, Dept Cognit Neurosci, Cognit & Behav,Med Ctr, Nijmegen, Netherlands
[8] Amer Univ Beirut, Dept Anesthesia, Div Neuroanesthesia, Med Ctr, Beirut, Lebanon
来源
FRONTIERS IN NEUROLOGY | 2019年 / 10卷
关键词
diffusion tensor imaging (DTI); autism spectrum disorder (ASD); applied behavior analysis (ABA) therapy; ASD interventional therapies; VB-MAPP assessment; FRONTAL-LOBE; DIFFUSION; CHILDREN; ATLAS;
D O I
10.3389/fneur.2019.00877
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: This pilot study aims to identify white matter (WM) tract abnormalities in Autism Spectrum Disorders (ASD) toddlers and pre-schoolers by Diffusion Tensor Imaging (DTI), and to correlate imaging findings with clinical improvement after early interventional and Applied Behavior Analysis (ABA) therapies by Verbal Behavior Milestones Assessment and Placement Program (VB-MAPP). Methods: DTI scans were performed on 17 ASD toddlers/pre-schoolers and seven age-matched controls. Nine ASD patients had follow-up MRI 12 months following early intervention and ABA therapy. VB-MAPP was assessed and compared at diagnosis, 6 and 12 months after therapies. Tract-Based Spatial Statistics (TBSS) was used to measure fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial (RD) diffusivity. Results: VB-MAPP scores improved at 6 and 12 months after early intervention and ABA therapy compared to scores at baseline. TBSS analysis showed significant FA decrease and/or RD increase in ASD patients before therapy vs. controls in inferior fronto-occipital fasciculi, uncinate fasciculi, left superior fronto-occipital fasciculus, forceps minor, left superior fronto-occipital fasciculus, right superior longitudinal fasciculus, corona radiate bilaterally, and left external capsule. A significantly FA increase in 21 tracts and ROIs is reported in post- vs. pre-therapy DTI analysis. Conclusion: DTI findings highlighted ASD patient WM abnormalities at diagnosis and confirmed the benefits of 12 months of early intervention and ABA therapy on clinical and neuro imaging outcomes.
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页数:10
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