Antiprion immunotherapy: To suppress or to stimulate?

被引：58
作者：
Aguzzi, A [1 ]
Sigurdson, CJ [1 ]
机构：
[1] Univ Zurich Hosp, Inst Neuropathol, CH-8091 Zurich, Switzerland
来源：
NATURE REVIEWS IMMUNOLOGY | 2004年 / 4卷 / 09期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nri1437
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Although human prion diseases are rare, they are invariably fatal, and treatments remain elusive. Hundreds of iatrogenic prion transmissions have occurred in the past two decades, and the bovine spongiform encephalopathy epidemic has raised concerns about prion transmission from cattle to humans. Research into therapeutics for prion disease is being pursued in several centres and prominently includes immunological strategies. Currently, the options that are being explored aim either to mobilize the innate and adaptive immune systems towards prion destruction or to suppress or dedifferentiate the lymphoreticular compartments that replicate prions. This article reviews the pathophysiology of prion diseases in mouse models and discusses their relevance to immunotherapeutic and immunoprophylactic antiprion strategies.
引用
收藏
页码：725 / 736
页数：12
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