Association between Landscape Factors and Spatial Patterns of Plasmodium knowlesi Infections in Sabah, Malaysia

被引：136

作者：

Fornace, Kimberly M. ^{[1
]}

Abidin, Tommy Rowel ^{[2
,3
]}

Alexander, Neal ^{[1
]}

Brock, Paddy ^{[4
]}

Grigg, Matthew J. ^{[2
,3
,5
]}

Murphy, Amanda ^{[5
]}

William, Timothy ^{[2
,3
,6
,7
]}

Menon, Jayaram ^{[7
]}

Drakeley, Chris J. ^{[1
]}

Cox, Jonathan ^{[1
]}

机构：

[1] London Sch Hyg & Trop Med, London WC1, England

[2] Infect Dis Soc, Kota Kinabalu, Malaysia

[3] Menzies Sch Hlth Res, Kota Kinabalu, Malaysia

[4] Univ Glasgow, Glasgow, Lanark, Scotland

[5] Menzies Sch Hlth Res, Darwin, NT, Australia

[6] Jesselton Med Ctr, Kota Kinabalu, Malaysia

[7] Sabah Dept Hlth, Kota Kinabalu, Malaysia

来源：

EMERGING INFECTIOUS DISEASES | 2016年 / 22卷 / 02期

基金：

英国医学研究理事会; 英国经济与社会研究理事会; 英国自然环境研究理事会;

关键词：

INCREASING INCIDENCE; VEGETATION INDEX; MALARIA; TRANSMISSION; FOREST; DEFORESTATION; EPIDEMIOLOGY; DIVERSITY; DENSITY; IMPACT;

D O I：

10.3201/eid2202.150656

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The zoonotic malaria species Plasmodium knowlesi has become the main cause of human malaria in Malaysian Borneo. Deforestation and associated environmental and population changes have been hypothesized as main drivers of this apparent emergence. We gathered village-level data for P. knowlesi incidence for the districts of Kudat and Kota Marudu in Sabah state, Malaysia, for 2008-2012. We adjusted malaria records from routine reporting systems to reflect the diagnostic uncertainty of microscopy for P. knowlesi. We also developed negative binomial spatial autoregressive models to assess potential associations between P knowlesi incidence and environmental variables derived from satellite-based remote-sensing data. Marked spatial heterogeneity in P knowlesi incidence was observed, and village-level numbers of P. knowlesi cases were positively associated with forest cover and historical forest loss in surrounding areas. These results suggest the likelihood that deforestation and associated environmental changes are key drivers in P. knowlesi transmission in these areas.

引用

页码：201 / 208

页数：8

共 40 条

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