Nucleophilic ring opening reactions of aziridines

被引：65

作者：

Akhtar, Rabia ^{[1
]}

Naqvi, Syed Ali Raza ^{[1
]}

Zahoor, Ameer Fawad ^{[1
]}

Saleem, Sameera ^{[1
]}

机构：

[1] Govt Coll Univ Faisalabad, Dept Chem, Faisalabad 38000, Pakistan

来源：

MOLECULAR DIVERSITY | 2018年 / 22卷 / 02期

关键词：

Aziridine; Biologically active compounds; Enantioselective synthesis; Ring opening reactions; Methodology development; ORTHOGONALLY PROTECTED AZALANTHIONINES; ACID CATALYZED ANNULATION; FORMAL 3+2 CYCLOADDITION; N-ACTIVATED AZIRIDINES; BETA-AMINO ALCOHOLS; ONE-POT SYNTHESIS; LEWIS-ACID; CHIRAL AZIRIDINE; MESO-AZIRIDINES; VINYL AZIRIDINES;

D O I：

10.1007/s11030-018-9829-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aziridine ring opening reactions have gained tremendous importance in the synthesis of nitrogen containing biologically active molecules. During recent years, a great effort has been put forward by scientists toward unique bond construction methodologies via ring opening of aziridines. In this regard, a wide range of chiral metal- and organo-catalyzed desymmetrization reactions of aziridines have been reported with carbon, sulfur, oxygen, nitrogen, halogen, and other nucleophiles. In this review, an outline of methodologies adopted by a number of scientists during 2013-2017 for aziridine ring opening reactions as well as their synthetic applications is described.

引用

收藏

页码：447 / 501

页数：55

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