Pd(II)-Catalyzed Olefination of Electron-Deficient Arenes Using 2,6-Dialkylpyridine Ligands

被引：470

作者：

Zhang, Yang-Hui ^{[1
]}

Shi, Bing-Feng ^{[1
]}

Yu, Jin-Quan ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 14期

基金：

美国国家卫生研究院;

关键词：

H BOND ACTIVATION; CARBON-HYDROGEN-BONDS; DIRECT ARYLATION; OXIDASE CATALYSIS; PALLADIUM ACETATE; MOLECULAR-OXYGEN; INDOLES; FUNCTIONALIZATION; MECHANISM; ANILIDES;

D O I：

10.1021/ja900327e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pd(II)-catalyzed meta-olefination of highly electron-deficient arenes is achieved through the use of a rationally designed mutually repulsive ligand. The combination of directed and nondirected C-H functionalization of arenes provides a versatile route for the synthesis of highly sought after 1,2,4-trisubstituted arenes.

引用

页码：5072 / +

页数：4

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