Molecular Evidence of Sexual Transmission of Ebola Virus

被引：320

作者：

Mate, S. E. ^{[1
]}

Kugelman, J. R. ^{[1
]}

Nyenswah, T. G. ^{[4
]}

Ladner, J. T. ^{[1
]}

Wiley, M. R. ^{[1
]}

Cordier-Lassalle, T. ^{[7
]}

Christie, A. ^{[7
,8
]}

Schroth, G. P. ^{[9
]}

Gross, S. M. ^{[9
]}

Davies-Wayne, G. J. ^{[5
]}

Shinde, S. A. ^{[10
]}

Murugan, R. ^{[5
]}

Sieh, S. B. ^{[4
]}

Badio, M. ^{[4
]}

Fakoli, L. ^{[6
]}

Taweh, F. ^{[6
]}

de Wit, E. ^{[11
]}

van Doremalen, N. ^{[11
]}

Munster, V. J. ^{[11
]}

Pettitt, J. ^{[3
]}

Prieto, K. ^{[1
]}

Humrighouse, B. W. ^{[8
]}

Stroeher, U. ^{[8
]}

DiClaro, J. W. ^{[12
]}

Hensley, L. E. ^{[3
]}

Schoepp, R. J. ^{[2
]}

Safronetz, D. ^{[11
]}

Fair, J. ^{[13
]}

Kuhn, J. H. ^{[3
]}

Blackley, D. J. ^{[8
]}

Laney, A. S. ^{[8
]}

Williams, D. E. ^{[8
]}

Lo, T. ^{[8
]}

Gasasira, A.

Nichol, S. T. ^{[8
]}

Formenty, P. ^{[7
]}

Kateh, F. N. ^{[4
]}

De Cock, K. M. ^{[8
]}

Bolay, F. ^{[6
]}

Sanchez-Lockhart, M. ^{[1
]}

Palacios, G. ^{[1
]}

机构：

[1] US Army Med Res Inst Infect Dis, Ctr Genome Sci, Frederick, MD 21702 USA

[2] US Army Med Res Inst Infect Dis, Diagnost Syst Div, Frederick, MD 21702 USA

[3] NIAID, Div Clin Res, Integrated Res Facil Ft Detrick, NIH, Frederick, MD USA

[4] Minist Hlth & Social Welf, Monrovia, Liberia

[5] WHO, Monrovia, Liberia

[6] Liberian Inst Biomed Res, Charlesville, Liberia

[7] WHO, Geneva, Switzerland

[8] Ctr Dis Control & Prevent, Atlanta, GA USA

[9] Illumina, San Diego, CA USA

[10] WHO, New Delhi, India

[11] NIAID, Rocky Mt Lab, Div Intramural Res, NIH, Hamilton, MT 59840 USA

[12] Naval Med Res Unit 3, Cairo, Egypt

[13] Fdn Merieux, Washington, DC USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2015年 / 373卷 / 25期

关键词：

SIERRA-LEONE; OUTBREAK; LIBERIA; CONGO; PERSISTENCE; EVOLUTION; DISEASE; KIKWIT; GUINEA;

D O I：

10.1056/NEJMoa1509773

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A suspected case of sexual transmission from a male survivor of Ebola virus disease (EVD) to his female partner (the patient in this report) occurred in Liberia in March 2015. Ebola virus (EBOV) genomes assembled from blood samples from the patient and a semen sample from the survivor were consistent with direct transmission. The genomes shared three substitutions that were absent from all other Western African EBOV sequences and that were distinct from the last documented transmission chain in Liberia before this case. Combined with epidemiologic data, the genomic analysis provides evidence of sexual transmission of EBOV and evidence of the persistence of infective EBOV in semen for 179 days or more after the onset of EVD.

引用

页码：2448 / 2454

页数：7

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