Orthostatic hypotension: A review

被引：68

作者：

Joseph, Adrien ^{[1
]}

Wanono, Ruben ^{[1
,2
]}

Flamant, Martin ^{[1
,2
,3
]}

Vidal-Petiot, Emmanuelle ^{[1
,2
,3
]}

机构：

[1] Hop Bichat Claude Bernard, DHU Fire, Serv Physiol, 46 Rue Henri Huchard, F-75018 Paris, France

[2] Univ Paris Diderot, Sorbonne Paris Cite, 46 Rue Henri Huchard, F-75018 Paris, France

[3] Lnserm, U1149, 46 Rue Henri Huchard, F-75018 Paris, France

来源：

NEPHROLOGIE & THERAPEUTIQUE | 2017年 / 13卷

关键词：

Orthostatic hypotension; Autonomic nervous system; Synucleopathies; Baroreflex; ACUTE AUTONOMIC NEUROPATHY; SYSTOLIC BLOOD-PRESSURE; ARTERIAL BAROREFLEX SENSITIVITY; INAPPROPRIATE SINUS TACHYCARDIA; MULTIPLE SYSTEM ATROPHY; GUILLAIN-BARRE-SYNDROME; POSTURAL HYPOTENSION; PARKINSONS-DISEASE; POSTPRANDIAL HYPOTENSION; ATHEROSCLEROSIS RISK;

D O I：

10.1016/j.nephro.2017.01.003

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Orthostatic hypotension, defined by a drop in blood pressure of at least 20 mmHg for systolic blood pressure and at least 10 mmHg for diastolic blood pressure within 3 minutes of standing up, is a frequent finding, particularly in elderly patients. It is associated with a significant increase in morbidity and mortality. Although it is often multifactorial, the first favoring factor is medications. Other etiologies are divided in neurogenic orthostatic hypotension, characterized by autonomic failure due to central or peripheral nervous system disorders, and non-neurogenic orthostatic hypotension, mainly favoured by hypovolemia. Treatment always requires education of the patient regarding triggering situations and physiological countermanoeuvers. Pharmacological treatment may sometimes be necessary and mainly relies on volume expansion by fiudrocortisone and/or a vasopressor agents such as midodrine. There is no predefined blood pressure target, the goal of therapy being the relief of symptoms and fall prevention. (C) 2017 Association Societe de nephrologie. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：S55 / S67

页数：13

共 184 条

[71] Droxidopa for neurogenic orthostatic hypotension A randomized, placebo-controlled, phase 3 trial [J].